SGMS1 and STK4

Number of citations of the paper that reports this interaction (PubMedID 22863277)
47

Data Source:
BioGRID (enzymatic study)

		SGMS1	STK4
Description		sphingomyelin synthase 1	serine/threonine kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Ceramide Phosphoethanolamine Synthase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Sphingomyelin Synthase Activity Ceramide Cholinephosphotransferase Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Apoptotic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Anatomical Structure Morphogenesis Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways		Sphingolipid de novo biosynthesis	Signaling by Hippo
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cobalt levels ( 26025379) LDL cholesterol levels ( 32203549) Metabolite levels ( 31628463) Neurological blood protein biomarker levels ( 31320639) Pulse pressure ( 30578418) Response to amphetamines ( 22952603) Schizophrenia ( 34099189) Triglyceride levels ( 32203549)	Bipolar disorder ( 31043756 33263727 34002096) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		2 interacting genes: ATXN1 STK4	25 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 HSPA4 IL2RG KEAP1 LATS1 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 RNF6 SAV1 SGMS1 SIRT1 THAP12 TP53 TRIM69
Entrez ID		259230	6789
HPRD ID		18203	05395
Ensembl ID		ENSG00000198964	ENSG00000101109
Uniprot IDs		E6ZCI6 Q86VZ5	A0A087WVN8 Q13043
PDB IDs			2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT 8A5J 8PAV 8PAW
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport POZ Domain Binding Positive Regulation Of Hepatocyte Apoptotic Process Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neural Tube Formation Nuclear Inclusion Body Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Protein-containing Complex Positive Regulation Of Cell Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process Embryonic Hemopoiesis Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Hippo Signaling Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Embryonic Epithelial Tube Formation Hippo Signaling Insulin-like Growth Factor Receptor Signaling Pathway Epithelial Tube Formation Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Organ Growth Branching Involved In Blood Vessel Morphogenesis Visual Behavior Negative Regulation Of Signal Transduction Visual Learning Regulation Of Glial Cell Proliferation Positive Regulation Of Gliogenesis Cellular Localization Excitatory Postsynaptic Potential Social Behavior Negative Regulation Of Cell Communication Positive Regulation Of Developmental Process Animal Organ Development Lung Alveolus Development Establishment Of Localization In Cell Intracellular Transport Regulation Of Cell Differentiation Negative Regulation Of Signaling Regulation Of Hippo Signaling Peptidyl-serine Phosphorylation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Apoptotic Process Programmed Cell Death Regulation Of Autophagy Cell Death Intracellular Signal Transduction Regulation Of Macroautophagy Response To Stress Regulation Of Proteolysis Identical Protein Binding Regulation Of Protein Metabolic Process Keratinocyte Differentiation Positive Regulation Of Protein Metabolic Process Response To UV Immune System Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Hippo Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Regulation Of Glucose Metabolic Process Epidermal Cell Differentiation Glial Cell Apoptotic Process Regulation Of Programmed Necrotic Cell Death PML Body Keratin Filament Binding Signal Transduction Transcription Regulator Inhibitor Activity Positive Regulation Of Metabolic Process Regulation Of Endodeoxyribonuclease Activity Nucleus Regulation Of Post-translational Protein Modification T Cell Differentiation In Thymus Stress-induced Premature Senescence Protein Ubiquitination Post-translational Protein Modification Cytoplasm Regulation Of Hippo Signaling Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Leukocyte Apoptotic Process Cellular Response To Glucose Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Transcription By Glucose Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Signaling
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