SGMS1 and STK4

Number of citations of the paper that reports this interaction (PMID 22863277)
65

Data Source:
BioGRID (enzymatic study)

		SGMS1	STK4
Gene Name		sphingomyelin synthase 1	serine/threonine kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Nucleus Endoplasmic Reticulum Plasma Membrane Membrane Integral Component Of Golgi Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Kinase Activity Sphingomyelin Synthase Activity Ceramide Cholinephosphotransferase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process	Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Apoptotic Process Inflammatory Response Positive Regulation Of Gene Expression Cell Growth Phosphorylation Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cell Morphogenesis Patterning Of Blood Vessels Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	Signaling by Hippo
Drugs
Diseases
GWAS		Response to amphetamines ( 22952603)
Protein-Protein Interactions		2 interactors: ATXN1 STK4	16 interactors: AKT1 CASP3 CNKSR1 CSN1S1 HIST2H2BE IL2RG LATS1 MBP NEDD4 PRKRIR RASSF1 RASSF5 SAV1 SGMS1 SIRT1 TP53
Entrez ID		259230	6789
HPRD ID		18203	05395
Ensembl ID		ENSG00000198964	ENSG00000101109
Uniprot IDs		D3DWC4 Q86VZ5	Q13043
PDB IDs			2JO8 3COM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Primitive Hemopoiesis Tube Development Endocardium Development Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Hippo Signaling Negative Regulation Of Signaling Embryonic Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Phosphorylation Negative Regulation Of Organ Growth Regulation Of Phosphorus Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Patterning Of Blood Vessels Lung Alveolus Development Positive Regulation Of Fat Cell Differentiation	Response To Cytokine Positive Regulation Of Protein Metabolic Process Hippo Signaling Intracellular Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Helicase Activity Response To Stimulus Response To UV Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Aging Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Response To Radiation Response To Organic Substance Signal Transduction Cellular Response To Organic Substance Negative Regulation Of Protein Kinase Activity Apoptotic Mitochondrial Changes Cellular Response To Stimulus Response To Stress Negative Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Apoptotic Process Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Programmed Cell Death Keratinocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Neuron Death Cell Death Cellular Response To Hypoxia Death Positive Regulation Of Cell Death Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Autophagy Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Phosphorylation Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Aging Cellular Response To Oxygen Levels Negative Regulation Of Cell Proliferation Response To Light Stimulus Apoptotic Signaling Pathway
Tagcloud ?		abeta ad altering amyloid app brains cerebellum contributing generation hallmark hippocampus impacts lipids pathological pathology plaques precursor processing produce proteolysis put secondly sequential sphingomyelin synthase transmenbrane unclear viability	abl1 centered coactivator damage elicits hematologic hematological hippo inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Difference) ?		abeta ad altering amyloid app brains cerebellum contributing generation hallmark hippocampus impacts lipids pathological pathology plaques precursor processing produce proteolysis put secondly sequential sphingomyelin synthase transmenbrane unclear viability	abl1 centered coactivator damage elicits hematologic hematological hippo inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Intersection) ?