SGMS1

Description		sphingomyelin synthase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Ceramide Phosphoethanolamine Synthase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Sphingomyelin Synthase Activity Ceramide Cholinephosphotransferase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Apoptotic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cobalt levels ( 26025379) LDL cholesterol levels ( 32203549) Metabolite levels ( 31628463) Neurological blood protein biomarker levels ( 31320639) Pulse pressure ( 30578418) Response to amphetamines ( 22952603) Schizophrenia ( 34099189) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: ATXN1 STK4
Entrez ID		259230
HPRD ID		18203
Ensembl ID		ENSG00000198964
Uniprot IDs		E6ZCI6 Q86VZ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport POZ Domain Binding Positive Regulation Of Hepatocyte Apoptotic Process Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neural Tube Formation Nuclear Inclusion Body Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Protein-containing Complex Positive Regulation Of Cell Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process Embryonic Hemopoiesis Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Hippo Signaling Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Embryonic Epithelial Tube Formation Hippo Signaling Insulin-like Growth Factor Receptor Signaling Pathway Epithelial Tube Formation Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Organ Growth Branching Involved In Blood Vessel Morphogenesis Visual Behavior Negative Regulation Of Signal Transduction Visual Learning Regulation Of Glial Cell Proliferation Positive Regulation Of Gliogenesis Cellular Localization Excitatory Postsynaptic Potential Social Behavior Negative Regulation Of Cell Communication Positive Regulation Of Developmental Process Animal Organ Development Lung Alveolus Development Establishment Of Localization In Cell Intracellular Transport Regulation Of Cell Differentiation Negative Regulation Of Signaling Regulation Of Hippo Signaling Peptidyl-serine Phosphorylation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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