SPEF1 and KRTAP13-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPEF1	KRTAP13-2
Description		sperm flagellar 1	keratin associated protein 13-2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton Microtubule Plasma Membrane Microvillus Cilium Axoneme Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium Filopodium Motile Cilium Cell Projection Ciliary Tip 9+2 Motile Cilium Plasma Membrane Bounded Cell Projection Axonemal Central Apparatus	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Cytoskeletal Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Microtubule Bundle Formation Cilium Movement Negative Regulation Of Microtubule Depolymerization Cell Migration Cell Projection Organization Lamellipodium Assembly Filopodium Assembly Regulation Of Cytoskeleton Organization Axonemal Central Apparatus Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways			Keratinization
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal volume ( 29860282) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		6 interacting genes: CFTR CYSRT1 KRT40 KRTAP13-2 PLEKHF2 ZBED1	81 interacting genes: ANAPC11 ANXA11 BCL6 C22orf39 CBFA2T2 CCDC125 CCDC24 CCDC57 CCNK CFAP68 CRYBA1 CSKMT CYSRT1 ENKD1 EPDR1 ETFDH FANCL FBXO17 FCHO1 GATA3 GEMIN4 GNE GPS2 GRN HNRNPH1 HOXA1 HR KCTD9 KLHL38 KPRP KRT3 KRTAP1-1 KRTAP10-5 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-4 KRTAP4-5 KRTAP9-2 MAGOHB MEOX2 MGAT5B NBPF19 NEK8 NHLRC4 NOTCH2NLA OIP5 OTX1 P4HB PATZ1 PHETA1 PITX1 POU2AF1 RECK RHOXF2 SAXO4 SLC25A18 SLIT1 SMUG1 SNRPC SPEF1 SPMIP9 SSC4D STK16 TCAF1 TLE5 TNS2 TRAPPC6A TRIM68 TSPYL6 TSSK3 UNC5CL VGLL3 VWC2 YPEL3 ZIC1
Entrez ID		25876	337959
HPRD ID		09839	11201
Ensembl ID		ENSG00000101222	ENSG00000182816
Uniprot IDs		Q9Y4P9	Q52LG2
PDB IDs		2EE7
Enriched GO Terms of Interacting Partners?		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Protein Autosumoylation Positive Regulation Of Anion Channel Activity Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Keratin Filament Positive Regulation Of Monoatomic Anion Transport Spinal Cord Oligodendrocyte Cell Fate Specification Positive Regulation Of Enamel Mineralization Oligodendrocyte Cell Fate Specification Transepithelial Water Transport Spinal Cord Oligodendrocyte Cell Differentiation Intermediate Filament Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Glial Cell Fate Specification Structural Molecule Activity Bicarbonate Transmembrane Transporter Activity Early Endosome Membrane Intracellular PH Elevation Response To Ketone Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Type B Pancreatic Cell Differentiation Neuron Fate Determination	Intermediate Filament Keratin Filament Protein Binding
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