BACE2 and ABCA8

		BACE2	ABCA8
Description		beta-secretase 2	ATP binding cassette subfamily A member 8
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Melanosome Membrane Melanosome	Endoplasmic Reticulum Plasma Membrane Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Nucleotide Binding Lipid Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Protein Processing Peptide Hormone Processing Melanosome Organization Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid-beta Metabolic Process	Sphingomyelin Biosynthetic Process Xenobiotic Transmembrane Transport Lipid Transport Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Efflux Cholesterol Transport Cholesterol Efflux Xenobiotic Transport Transmembrane Transport
Pathways			ABC-family proteins mediated transport
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356) Systemic lupus erythematosus ( 32771030)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26582766) Coronary artery disease ( 29212778) Femur bone mineral density x serum urate levels interaction ( 34046847) Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899 32203549) High density lipoprotein cholesterol levels ( 33339817) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol ( 25961943) Phosphorus levels ( 29403010) Soluble VCAM-1 levels ( 31217265) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		5 interacting genes: APP GGA1 GGA2 PCM1 SNRNP70
Entrez ID		25825	10351
HPRD ID		05744	09790
Ensembl ID		ENSG00000182240	ENSG00000141338
Uniprot IDs		Q9Y5Z0	A0A0A0MSU4 O94911
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1 7D5B 7D5U 7F1G 7N4N
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Folding	Membrane Protein Ectodomain Proteolysis Melanosome Membrane Regulation Of Glycoprotein Biosynthetic Process Melanosome Organization Amyloid-beta Metabolic Process Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Glycoprotein Biosynthetic Process Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Aspartic-type Endopeptidase Activity Pigment Granule Organization Regulation Of Amyloid Precursor Protein Biosynthetic Process Membrane Protein Proteolysis Melanosome Hormone Metabolic Process Carbohydrate Homeostasis Protein Processing Trans-Golgi Network Glucose Homeostasis
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