GALE and PLA2G5

		GALE	PLA2G5
Description		UDP-galactose-4-epimerase	phospholipase A2 group V
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Endosome Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagolysosome Phagocytic Vesicle Recycling Endosome
	Molecular Function	UDP-N-acetylglucosamine 4-epimerase Activity UDP-glucose 4-epimerase Activity Isomerase Activity Identical Protein Binding Protein Homodimerization Activity	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity
	Biological Process	Galactose Metabolic Process Galactose Catabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway	Lipid Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Phagocytosis Phospholipid Catabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Leukotriene Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Negative Regulation Of T Cell Proliferation Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Arachidonate Secretion Positive Regulation Of Phagocytosis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Phagosome-lysosome Fusion Positive Regulation Of Opsonization Positive Regulation Of Antifungal Innate Immune Response Positive Regulation Of Phagosome Maturation
Pathways		Defective GALE causes EDG Galactose catabolism	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs		Uridine diphosphate glucose Uridine-Diphosphate-N-Acetylgalactosamine UDP-alpha-D-glucuronic acid Tetramethylammonium Uridine-Diphosphate-N-Acetylglucosamine Galactose-uridine-5'-diphosphate
Diseases		Galactosemia
GWAS			Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471)
Interacting Genes		1 interacting genes: APP	1 interacting genes: PLA2G4A
Entrez ID		2582	5322
HPRD ID		06092	03117
Ensembl ID		ENSG00000117308	ENSG00000127472
Uniprot IDs		A0A384NL38 Q14376	P39877
PDB IDs		1EK5 1EK6 1HZJ 1I3K 1I3L 1I3M 1I3N
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Golgi Lumen Recycling Endosome Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Antifungal Innate Immune Response Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Phagosome Maturation Regulation Of Phagosome Maturation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Phagolysosome Positive Regulation Of Phospholipase Activity Intermediate-density Lipoprotein Particle Regulation Of ERK1 And ERK2 Cascade Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Endocytosis Negative Regulation Of Cell Adhesion Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Positive Regulation Of Lipase Activity	UDP-glucose 4-epimerase Activity UDP-N-acetylglucosamine 4-epimerase Activity Organophosphate Catabolic Process Phosphatidylglycerol Catabolic Process Galactose Metabolic Process Galactose Catabolic Process Carbohydrate Metabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Platelet Activating Factor Metabolic Process Cellular Response To Antibiotic Calcium-independent Phospholipase A2 Activity Calcium-dependent Phospholipase A2 Activity Positive Regulation Of Platelet Activation Ether Lipid Biosynthetic Process Phosphatidylcholine Acyl-chain Remodeling Phosphatidylcholine Catabolic Process Ceramide 1-phosphate Binding Glycerol Metabolic Process Positive Regulation Of Prostaglandin Secretion Monoacylglycerol Biosynthetic Process Platelet Activating Factor Biosynthetic Process Negative Regulation Of Multicellular Organism Growth Regulation Of Store-operated Calcium Entry Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Phosphatidylinositol-5-phosphate Binding O-acyltransferase Activity Positive Regulation Of Fatty Acid Transport Positive Regulation Of Icosanoid Secretion Arachidonate Secretion Ether Lipid Metabolic Process Glycerophospholipid Catabolic Process Phosphatidylcholine Lysophospholipase Activity Positive Regulation Of T-helper 1 Type Immune Response Leukotriene Biosynthetic Process Decidualization Regulation Of Hormone Biosynthetic Process Phospholipase Activity Protein Homodimerization Activity Leukotriene Metabolic Process Phospholipase A2 Activity Positive Regulation Of Macrophage Activation Phosphatidylinositol-4-phosphate Binding Phosphatidylglycerol Metabolic Process Response To Vitamin D Regulation Of Fatty Acid Transport Prostaglandin Metabolic Process Prostanoid Metabolic Process Response To Antibiotic Carboxylic Ester Hydrolase Activity
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