ANKS4B and USH1C

Number of citations of the paper that reports this interaction (PubMedID 15461667)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ANKS4B	USH1C
Description		ankyrin repeat and sterile alpha motif domain containing 4B	USH1 protein network component harmonin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Microvillus Brush Border Cell Projection Plasma Membrane Bounded Cell Projection	Photoreceptor Outer Segment Photoreceptor Inner Segment Stereocilia Ankle Link Complex Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Brush Border Cilium Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Synapse
	Molecular Function	Protein Binding	Protein Binding Spectrin Binding
	Biological Process	Cell Differentiation Response To Endoplasmic Reticulum Stress Protein-containing Complex Assembly Protein Localization To Microvillus Brush Border Assembly	G2/M Transition Of Mitotic Cell Cycle Auditory Receptor Cell Morphogenesis Sensory Perception Of Sound Parallel Actin Filament Bundle Assembly Cell Differentiation Regulation Of Microvillus Length Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Photoreceptor Cell Maintenance Retinal Cone Cell Development Neuromuscular Process Controlling Balance Sensory Perception Of Light Stimulus Equilibrioception Actin Filament Bundle Assembly Inner Ear Receptor Cell Stereocilium Organization Protein-containing Complex Assembly Protein Localization To Microvillus Brush Border Assembly
Pathways			Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases			Deafness, autosomal recessive Usher syndrome (US)
GWAS		Pelvic organ prolapse ( 26545240)	Body mass index ( 26426971) Macular thickness ( 30535121) Night sleep phenotypes ( 27126917)
Interacting Genes		5 interacting genes: APP LRRK2 MFHAS1 SMURF1 USH1C	13 interacting genes: ANKS4B CDH23 CTNNAL1 ENKD1 FBXO7 MIPOL1 MYO7A PCDHB12 PRKAA2 QKI RAC1 USH1G USHBP1
Entrez ID		257629	10083
HPRD ID		08794	09241
Ensembl ID		ENSG00000175311	ENSG00000006611
Uniprot IDs		Q8N8V4	A0A0S2Z4U9 A0A0S2Z4V1 Q9Y6N9
PDB IDs			1X5N 2KBQ 2KBR 2KBS 2LSR 3K1R 5F3X 5MV8 5MV9 5XBF 7X2E
Enriched GO Terms of Interacting Partners?		Regulation Of Plasma Membrane Bounded Cell Projection Organization Golgi-associated Vesicle Regulation Of Cell Projection Organization Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Positive Regulation Of Proteolysis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Protein Localization To Nucleus Modulation Of Excitatory Postsynaptic Potential Regulation Of Proteolysis Regulation Of Macrophage Activation Axon Cellular Developmental Process Regulation Of Inflammatory Response Microvillus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Lysosome Positive Regulation Of MAPK Cascade Amylin Binding Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Defense Response Negative Regulation Of Cell Communication Engulfment Of Target By Autophagosome Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Calcium-mediated Signaling Positive Regulation Of Catabolic Process Positive Regulation Of JNK Cascade Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Acetylcholine Receptor Activator Activity Regulation Of Cell Activation Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Nervous System Process Regulation Of MAPK Cascade	Equilibrioception Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Inner Ear Receptor Cell Stereocilium Organization Photoreceptor Inner Segment Inner Ear Morphogenesis Kinocilium Photoreceptor Cell Cilium Auditory Receptor Cell Stereocilium Organization Inner Ear Auditory Receptor Cell Differentiation Neuron Differentiation Hair Cell Differentiation Spectrin Binding Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Plasma Membrane Bounded Cell Projection Embryonic Morphogenesis Plasma Membrane Bounded Cell Projection Organization Cochlea Development Neuron Projection Development Sensory Perception Of Light Stimulus Photoreceptor Cell Maintenance Photoreceptor Connecting Cilium Stereocilium Ciliary Base Upper Tip-link Density Cell Differentiation Myosin VII Complex Internal N(7)-methylguanine-containing RNA Reader Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Inner Ear Development Cell Projection Organization Actin Filament-based Movement Microvillus Ciliary Basal Body [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Myofibroblast Contraction Negative Regulation Of MiRNA Catabolic Process Cochlear Hair Cell Ribbon Synapse Protein Localization To Microvillus
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