NEGR1 and LSAMP

Number of citations of the paper that reports this interaction (PubMedID 21982860)
0

Data Source:
BioGRID (pull down)

		NEGR1	LSAMP
Description		neuronal growth regulator 1	limbic system associated membrane protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Postsynaptic Density Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Apical Dendrite Side Of Membrane	Extracellular Region Cytosol Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Adhesion Brain Development Locomotory Behavior Feeding Behavior Positive Regulation Of Neuron Projection Development Neuron Projection Development Social Behavior Cholesterol Homeostasis Fat Cell Differentiation Positive Regulation Of Saliva Secretion Neuron Projection Morphogenesis Positive Regulation Of Calcium-mediated Signaling Regulation Of Synapse Assembly Negative Regulation Of Synapse Assembly Negative Regulation Of Glial Cell Proliferation Skeletal Muscle Organ Development Cell-cell Adhesion Lipid Droplet Formation	Cell Adhesion Nervous System Development
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption (drinks per week) ( 30643258) Allergic rhinitis ( 30013184) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 29273806) Asthma and major depressive disorder ( 31619474) Beef consumption ( 32066663) Bipolar disorder or body mass index ( 31754094) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body composition traits ( 30026463) Body mass index ( 26961502 28892062 28448500 19079261 26426971 31888951 25673413 23563607 19079260 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Broad depression or major depressive disorder (self-reported) ( 30626913) Cervical high-risk human papilloma virus infection ( 33225922) Childhood body mass index ( 26604143 33045005) Chromium levels ( 26025379) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Diffusing capacity of carbon monoxide ( 30694715) Experiencing mood swings ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heel bone mineral density ( 30598549) Hemostatic factors and hematological phenotypes ( 17903294) Hip circumference ( 25673412) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Meat-related diet ( 32066663) Menarche (age at onset) ( 25231870) Mental health study participation (completed survey) ( 31263887) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity ( 23563607) Obesity (early onset extreme) ( 23563609) Obesity (extreme) ( 30677029 31888951) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Rosacea symptom severity ( 29771307) Self-reported risk-taking behaviour ( 30271922) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Subcutaneous adipose tissue ( 22589738) Systemic lupus erythematosus ( 18204098) Urinary sodium excretion ( 31409800) Venlafaxine response in generalised anxiety disorder (HAMA-A score reduction after 24 weeks) ( 28437668) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 19079260)	Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) BMI x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Chronotype ( 30696823) Colorectal or endometrial cancer ( 26621817) Emphysema imaging phenotypes ( 26030696) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Itch intensity from mosquito bite adjusted by bite size ( 28199695) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Systemising ( 31508503) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Triglyceride levels ( 34074324)
Interacting Genes		2 interacting genes: LSAMP NTM	3 interacting genes: NEGR1 NTM PRNP
Entrez ID		257194	4045
HPRD ID		14820	09128
Ensembl ID		ENSG00000172260	ENSG00000185565
Uniprot IDs		Q7Z3B1	B7Z661 Q13449
PDB IDs		6DLD 6U6T
Enriched GO Terms of Interacting Partners?		Side Of Membrane Choline Transmembrane Transporter Activity Choline Transport	Side Of Membrane Positive Regulation Of Calcium-mediated Signaling Type 8 Metabotropic Glutamate Receptor Binding Regulation Of Calcium-mediated Signaling ATPase Complex Proton-transporting V-type ATPase, V1 Domain Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Extrinsic Component Of Synaptic Vesicle Membrane Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V1 Domain Proton-transporting V-type ATPase Complex Intracellular Monoatomic Cation Homeostasis Endosomal Lumen Acidification Chemical Homeostasis Inorganic Ion Homeostasis Homeostatic Process Cellular Response To Increased Oxygen Levels ATP-dependent Protein Binding Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Density Inclusion Body Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Interleukin-17 Production Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Extrinsic Component Of Membrane Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Dendrite Dendritic Spine Maintenance Cuprous Ion Binding Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Copper Ion Homeostasis Regulation Of Synapse Organization Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Apical Dendrite Lipid Droplet Formation Positive Regulation Of Saliva Secretion Negative Regulation Of Synapse Organization Positive Regulation Of Digestive System Process Negative Regulation Of Synapse Assembly
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