SYCE2 and MED11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYCE2	MED11
Description		synaptonemal complex central element protein 2	mediator complex subunit 11
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GO Annotations	Cellular Component	Central Element Nucleus Nucleoplasm Chromosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Synaptonemal Complex Assembly Cell Division Meiotic Cell Cycle	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Meiotic synapsis	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494)
Interacting Genes		12 interacting genes: CCDC196 CDC37 GAD2 HOMER1 IFT20 KIFC3 MED11 NAP1L5 TEX12 TRIM69 TRIML2 TSNAX	14 interacting genes: ABI2 APP CCDC120 CFTR GCSH MED22 MED8 MED9 NDEL1 NME7 SGF29 SSC5D SYCE2 USHBP1
Entrez ID		256126	400569
HPRD ID		19522	14709
Ensembl ID		ENSG00000161860	ENSG00000161920
Uniprot IDs		Q6PIF2	I3L3E8 Q9P086
PDB IDs		6R17 6YQF	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?			Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Transport Along Microtubule Protein-DNA Complex Assembly Cytoskeleton-dependent Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Microtubule-based Transport Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Gene Expression, Epigenetic Cellular Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Cell Projection Morphogenesis Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Endosome To Plasma Membrane Transport Vesicle Cellular Component Assembly Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport PDZ Domain Binding Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Aminomethyltransferase Activity
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