MMS22L and KRT37

		MMS22L	KRT37
Description		MMS22 like, DNA repair protein	keratin 37
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol FACT Complex Site Of Double-strand Break MCM Complex Nuclear Replication Fork Site Of DNA Damage	Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization DNA Damage Response Replication Fork Processing Protein Localization To Chromatin	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization
Pathways			Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Adult body size ( 32376654) Anxiety ( 33859377) Automobile speeding propensity ( 30643258) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Chronotype ( 30696823) Gut microbiota (bacterial taxa) ( 27694959) Hand grip strength ( 29691431) Morning person ( 30696823) Multiple sclerosis (OCB status) ( 23785401) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Squamous cell lung carcinoma ( 28604730)
Interacting Genes		4 interacting genes: ESCO2 FBXW7 RAD51 RPA1	47 interacting genes: AGXT AQP1 BCAS2 BFSP2 C21orf58 CCDC196 CLCNKA COL8A1 DES FAM110A FBXW5 GNG13 HAPLN2 HGS HOXA1 HSF4 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT76 KRT78 KRT79 KRT8 KRT81 KRT83 KRT85 KRT86 MTG1 NUFIP2 OIP5 OTX1 PIN1 PKN1 PSMA1 SMARCD1 SMARCE1 TBC1D21 TXLNB USHBP1
Entrez ID		253714	8688
HPRD ID		12865	05175
Ensembl ID		ENSG00000146263	ENSG00000108417
Uniprot IDs		E2QRD4 Q6ZRQ5	O76014
PDB IDs
Enriched GO Terms of Interacting Partners?		Lateral Element Site Of Double-strand Break Chromosome Organization Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cellular Response To Stress Condensed Chromosome Response To Glucoside Double-strand Break Repair Condensed Nuclear Chromosome DNA Repair Male Germ Cell Nucleus Negative Regulation Of Establishment Of Blood-brain Barrier Sister Chromatid Cohesion Positive Regulation Of Translational Initiation In Response To Stress Response To Unfolded Protein Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Mitotic Recombination-dependent Replication Fork Processing DNA Metabolic Process DNA Damage Response DNA Strand Exchange Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Presynaptic Intermediate Filament Cytoskeleton Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Dendritic Transport Of Mitochondrion Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Arginyl-tRNA Aminoacylation Arginine-tRNA Ligase Activity Post-translational Protein Acetylation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Meiotic Cell Cycle DNA Strand Invasion Telomere Maintenance Single-stranded DNA Binding DNA Recombinase Assembly Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Toxic Substance PML Body Single-stranded Telomeric DNA Binding Protein Localization To Chromosome Vitamin E Metabolic Process Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Ubiquitin Recycling	Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratinization Keratin Filament Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Extracellular Exosome Epidermis Development Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Cytosol Developmental Process Cornified Envelope Brahma Complex NpBAF Complex Tissue Development RSC-type Complex NBAF Complex Protein Binding Peptide Cross-linking
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