FNDC5 and PTS

Number of citations of the paper that reports this interaction (PubMedID 11591653)
29

Data Source:
HPRD (two hybrid, in vivo)

		FNDC5	PTS
Description		fibronectin type III domain containing 5	6-pyruvoyltetrahydropterin synthase
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GO Annotations	Cellular Component	Extracellular Region Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Plasma Membrane Membrane	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Hormone Activity	6-pyruvoyltetrahydropterin Synthase Activity Protein Binding Lyase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction Response To Muscle Activity Positive Regulation Of Brown Fat Cell Differentiation	Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development Tetrahydrobiopterin Metabolic Process
Pathways			Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Mycophenolate mofetil Biopterin
Diseases			Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Daytime nap ( 33568662)	Heel bone mineral density ( 30598549) Objective response to lithium treatment ( 26503763)
Interacting Genes		2 interacting genes: PTS TRPC3	11 interacting genes: AP2M1 COIL DDIT4L FNDC5 FXR2 LNX1 NTAQ1 PBRM1 PRKG2 SDCBP THAP10
Entrez ID		252995	5805
HPRD ID		17009	11840
Ensembl ID		ENSG00000160097	ENSG00000150787
Uniprot IDs		A0A0A0MRR6 Q8NAU1	Q03393
PDB IDs		4LSD	3I2B
Enriched GO Terms of Interacting Partners?		6-pyruvoyltetrahydropterin Synthase Activity Tetrahydrobiopterin Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex Calcium-activated Cation Channel Activity Store-operated Calcium Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Diol Metabolic Process Pteridine-containing Compound Metabolic Process Response To ATP Positive Regulation Of Cardiac Muscle Hypertrophy Phototransduction Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transmembrane Transport Detection Of Light Stimulus Regulation Of Cardiac Muscle Hypertrophy Calcium Channel Activity Single Fertilization Positive Regulation Of Calcium Ion Transport Detection Of Abiotic Stimulus Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport
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