FNDC5 and PTS

Number of citations of the paper that reports this interaction (PMID 11591653)
37

Data Source:
HPRD (in vivo, two hybrid)

		FNDC5	PTS
Gene Name		fibronectin type III domain containing 5	6-pyruvoyltetrahydropterin synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Peroxisomal Membrane Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Molecular_function Hormone Activity	6-pyruvoyltetrahydropterin Synthase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Biological_process Response To Muscle Activity Positive Regulation Of Brown Fat Cell Differentiation	Cellular Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity
Pathways			Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: PTS	12 interactors: ATM ATR COIL FNDC5 FXR2 LNX1 PBRM1 PRKDC PRKG2 SDCBP THAP10 WDYHV1
Entrez ID		252995	5805
HPRD ID		17009	11840
Ensembl ID		ENSG00000160097	ENSG00000150787
Uniprot IDs		Q8NAU1	Q03393
PDB IDs			3I2B
Enriched GO Terms of Interacting Partners?		Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Pteridine-containing Compound Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Pteridine-containing Compound Metabolic Process Regulation Of Oxidoreductase Activity Reactive Oxygen Species Metabolic Process Coenzyme Biosynthetic Process Cofactor Metabolic Process	Peptidyl-serine Phosphorylation Response To Gamma Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Replicative Senescence Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Response To Ionizing Radiation DNA Damage Checkpoint Double-strand Break Repair Cellular Response To Gamma Radiation V(D)J Recombination Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Protein Autophosphorylation Cell Cycle Checkpoint DNA Recombination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Heat Negative Regulation Of Protein Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Telomere Maintenance Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Peptidyl-amino Acid Modification Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Somitogenesis Cell Cycle Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Somite Development Mitotic DNA Damage Checkpoint Cellular Protein Modification Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle B Cell Differentiation Response To Heat Segmentation Heart Development Regulation Of Response To DNA Damage Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition
Tagcloud ?		adipokine adipose adiposity arose artefact attempt circulating circulation clarify controversy counteract disturbances doubts fibronectin homoeostasis humans inconsistencies irisin obesity participation pathologies postulated proliferated questionable raise really reflecting soon unpredicted	achieve aida apl atra became chemotherapy consolidation converting courses cytogenetic fab gimema hematologic interpretation lap0493 m3 majority molecularly morphologic mths myelogenous persistence promyelocytic q12 q22 remission successive transcript validity
Tagcloud (Difference) ?		adipokine adipose adiposity arose artefact attempt circulating circulation clarify controversy counteract disturbances doubts fibronectin homoeostasis humans inconsistencies irisin obesity participation pathologies postulated proliferated questionable raise really reflecting soon unpredicted	achieve aida apl atra became chemotherapy consolidation converting courses cytogenetic fab gimema hematologic interpretation lap0493 m3 majority molecularly morphologic mths myelogenous persistence promyelocytic q12 q22 remission successive transcript validity
Tagcloud (Intersection) ?