CADM1 and PSMA6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CADM1	PSMA6
Gene Name		cell adhesion molecule 1	proteasome (prosome, macropain) subunit, alpha type, 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Synaptic Vesicle Integral Component Of Membrane Basolateral Plasma Membrane Axon Dendrite Extracellular Vesicular Exosome	Proteasome Complex Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Polysome Nuclear Matrix Proteasome Core Complex, Alpha-subunit Complex Myofibril Sarcomere Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding	RNA Binding Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Purine Ribonucleoside Triphosphate Binding NF-kappaB Binding
	Biological Process	Liver Development T Cell Mediated Cytotoxicity Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Spermatogenesis Synapse Assembly Brain Development Cell Recognition Unidimensional Cell Growth Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell Differentiation Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cytokine Secretion Activated T Cell Proliferation Detection Of Stimulus Bone Development	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 20838585) Obesity-related traits ( 23251661)	Psoriasis ( 20953189)
Protein-Protein Interactions		6 interactors: ATF7IP CASK EPB41L3 MPP3 PSMA6 SDCBP	21 interactors: BRCA1 C19orf57 CADM1 ECT2 KRTAP4-2 LIG4 LIMD2 PAXIP1 PLK1 PSMA2 PSMA3 PSMA4 PSMA7 PSMB5 PSMB6 PSMB8 RNF170 RTP5 TRIM39 USP4 ZBTB44
Entrez ID		23705	5687
HPRD ID		05746	04171
Ensembl ID		ENSG00000182985	ENSG00000100902
Uniprot IDs		A0A4Z1 Q9BY67	B4DQR4 B4DXJ9 P60900
PDB IDs		3BIN 4H5S
Enriched GO Terms of Interacting Partners?		Nucleotide Phosphorylation	Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction By P53 Class Mediator Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Checkpoint Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Checkpoint Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Apoptotic Process Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Process Programmed Cell Death Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Cell Death Death Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Tagcloud ?		125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma1 psma3 psma5 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies
Tagcloud (Difference) ?		125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma1 psma3 psma5 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies
Tagcloud (Intersection) ?