ELP5 and ELP4

Number of citations of the paper that reports this interaction (PubMedID 36617428)
102

Data Source:
BioGRID (pull down)

		ELP5	ELP4
Description		elongator acetyltransferase complex subunit 5	elongator acetyltransferase complex subunit 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Elongator Holoenzyme Complex	Nucleus Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	TRNA Binding Protein Binding	Protein Binding Phosphorylase Kinase Regulator Activity
	Biological Process	TRNA Wobble Uridine Modification TRNA Modification Regulation Of Translation TRNA Processing Positive Regulation Of Cell Migration	TRNA Wobble Uridine Modification Regulation Of Transcription By RNA Polymerase II Regulation Of Translation TRNA Processing
Pathways		HATs acetylate histones	HATs acetylate histones
Drugs
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Glaucoma ( 25027321) Mental health study participation (completed survey) ( 31263887) Optic disc area ( 25631615) Optic disc size ( 31809533) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		3 interacting genes: ATXN1 ELP4 RHOU	4 interacting genes: ELP5 ELP6 HINFP PPP1CC
Entrez ID		23587	26610
HPRD ID		08520	07377
Ensembl ID		ENSG00000170291	ENSG00000109911
Uniprot IDs		A0AAG2TUE2 Q8TE02	G5E9D4 Q96EB1
PDB IDs
Enriched GO Terms of Interacting Partners?			Elongator Holoenzyme Complex TRNA Wobble Uridine Modification TRNA Modification TRNA Processing RNA Modification TRNA Metabolic Process Squalene Synthase [NAD(P)H] Activity Inflammasome-mediated Signaling Pathway TRNA Uridine(34) Acetyltransferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity TRNA Binding Regulation Of Translation Cytoplasmic Pattern Recognition Receptor Signaling Pathway N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Homeostasis Of Number Of Retina Cells TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Phosphorylase Kinase Regulator Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility N-acetylglucosamine Catabolic Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Locomotion Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Farnesyl Diphosphate Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Ubiquitin Recycling Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Catabolic Process PTW/PP1 Phosphatase Complex Innate Immune Response-activating Signaling Pathway Protein Linear Polyubiquitination Activation Of Innate Immune Response Intracellular Receptor Signaling Pathway UDP-N-acetylglucosamine Biosynthetic Process MAPK Cascade RNA Processing Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Metabolic Process Intracellular Signal Transduction
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