PIGN and FJX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PIGN	FJX1
Description		phosphatidylinositol glycan anchor biosynthesis class N	four-jointed box kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	Transferase Activity Mannose-ethanolamine Phosphotransferase Activity
	Biological Process	GPI Anchor Biosynthetic Process	Cell-cell Signaling Retina Layer Formation
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Bone mineral density (hip) ( 30172743) Femoral neck bone mineral density ( 30172743)
Interacting Genes		1 interacting genes: FJX1	2 interacting genes: DKKL1 PIGN
Entrez ID		23556	24147
HPRD ID		12085	16897
Ensembl ID		ENSG00000197563	ENSG00000179431
Uniprot IDs		A0A1W2PNR0 A0A1W2PPR7 A0A1W2PQA9 O95427	Q86VR8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Platelet-derived Growth Factor Production Regulation Of Platelet-derived Growth Factor Production Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Collagen Biosynthetic Process Retina Layer Formation Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Serine-type Endopeptidase Inhibitor Activity	Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Mannose-ethanolamine Phosphotransferase Activity Negative Regulation Of Testosterone Biosynthetic Process Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Diaphragm Development Regulation Of Female Gonad Development Positive Regulation Of Male Gonad Development S-shaped Body Morphogenesis Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Regulation Of Testosterone Biosynthetic Process Nephron Tubule Morphogenesis Podocyte Differentiation Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Penetration Of Zona Pellucida Receptor Antagonist Activity Co-receptor Binding Metanephric Epithelium Development Muscle Cell Fate Commitment Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Glomerulus Development C2H2 Zinc Finger Domain Binding Male Genitalia Development Mesenchymal To Epithelial Transition Positive Regulation Of Apoptotic Process Renal Tubule Morphogenesis Positive Regulation Of Programmed Cell Death Skeletal Muscle Organ Development Cellular Response To Gonadotropin Stimulus Circulatory System Development Regulation Of Ketone Biosynthetic Process Sex Determination Reproductive System Development Adrenal Gland Development Negative Regulation Of Steroid Biosynthetic Process Response To Gonadotropin GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Negative Regulation Of Steroid Metabolic Process
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