MORC3 and SETD4

		MORC3	SETD4
Description		MORC family CW-type zinc finger 3	SET domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Matrix PML Body	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding RNA Binding Protein Binding Zinc Ion Binding ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Histone H3K4me3 Reader Activity	Transcription Coactivator Activity Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H3K4 Methyltransferase Activity Histone H3K36 Methyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity Histone H3K4 Monomethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Chromatin Organization Protein Phosphorylation Post-embryonic Development Peptidyl-serine Phosphorylation Negative Regulation Of Interferon-beta Production Innate Immune Response Negative Regulation Of Fibroblast Proliferation Protein Stabilization Maintenance Of Protein Location In Nucleus Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Cellular Senescence	Chromatin Remodeling Inflammatory Response Methylation Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Regulation Of Cell Proliferation In Bone Marrow
Pathways
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Height ( 31562340)	Asthma (adult onset) ( 31036433) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Obesity-related traits ( 23251661)
Interacting Genes		25 interacting genes: ARK2N COPS5 DST DYNLL1 ERCC6 KALRN KIF3A KPNA2 KPNA4 MKLN1 PIAS1 PIAS3 PTK2 RANBP9 RETREG1 RNF123 RNF216 SNAPIN SPTBN4 SRI SUMO2 SUMO3 UBC UBE2I ZMYM5	1 interacting genes: CIAO2A
Entrez ID		23515	54093
HPRD ID		10316	10743
Ensembl ID		ENSG00000159256	ENSG00000185917
Uniprot IDs		B4DHJ4 Q14149 Q4VBZ9	A8MTS1 Q9NVD3
PDB IDs		4QQ4 5SVI 5SVX 5SVY 6O1E 6O5W
Enriched GO Terms of Interacting Partners?		Protein Sumoylation SUMO Transferase Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Post-translational Protein Modification PML Body Protein Modification Process Protein Tag Activity Axon Cytoplasm Protein Metabolic Process Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Nucleoplasm Macromolecule Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Transport Microtubule Anchoring At Centrosome Cellular Localization Axonal Transport Negative Regulation Of Heart Rate SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Microtubule Anchoring At Microtubule Organizing Center Transport Along Microtubule Cell Cortex Axo-dendritic Transport Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Cytosol Microtubule-based Transport Nuclear Import Signal Receptor Activity Retrograde Axonal Transport Negative Regulation Of Heart Contraction Cytoplasm Enzyme Binding Nuclear Localization Sequence Binding Negative Regulation Of Blood Circulation Regulation Of Protein Sumoylation NLS-bearing Protein Import Into Nucleus Microtubule Anchoring Regulation Of Protein Modification Process Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Spectrin Binding Proteolysis Involved In Protein Catabolic Process Establishment Of Organelle Localization Vesicle Localization
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