POFUT1 and ID1

		POFUT1	ID1
Description		protein O-fucosyltransferase 1	inhibitor of DNA binding 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transferase Activity Glycosyltransferase Activity Peptide-O-fucosyltransferase Activity	Transcription Corepressor Activity Protein Binding Protein Dimerization Activity Transcription Regulator Inhibitor Activity
	Biological Process	Angiogenesis Somitogenesis Fucose Metabolic Process Protein Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway Protein O-linked Glycosylation Via Fucose	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Neuron Differentiation BMP Signaling Pathway Protein Destabilization Collagen Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Blood Vessel Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Response To Antibiotic Rhythmic Process Blood Vessel Morphogenesis Lung Morphogenesis Lung Vasculature Development Endothelial Cell Apoptotic Process Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum	Oncogene Induced Senescence NGF-stimulated transcription Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)	Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		4 interacting genes: AKT2 DLL1 JAG1 NOTCH1	26 interacting genes: APPL1 ASCL3 CASK COPB1 DNMT3L ELK1 ELK4 GATA4 HES1 IFI16 IKBKG MSGN1 MYF5 MYF6 MYOD1 MYOG PSMD4 RNF4 RUNX1T1 SUV39H1 TCF12 TCF3 TCF4 TRIM55 TRIM63 UBC
Entrez ID		23509	3397
HPRD ID		06319	08980
Ensembl ID		ENSG00000101346	ENSG00000125968
Uniprot IDs		Q9H488	P41134
PDB IDs		5UX6 5UXH
Enriched GO Terms of Interacting Partners?		Neuron Differentiation Inhibition Of Neuroepithelial Cell Differentiation Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Left/right Axis Specification Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Inner Ear Receptor Cell Differentiation Epidermal Cell Differentiation Nephron Tubule Development Renal Tubule Development Neuronal Stem Cell Population Maintenance Notch Binding Mechanoreceptor Differentiation Tube Morphogenesis Stem Cell Population Maintenance Maintenance Of Cell Number Neuroepithelial Cell Differentiation Distal Tubule Development Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Positive Regulation Of Notch Signaling Pathway Loop Of Henle Development Negative Regulation Of Epithelial Cell Differentiation Epithelial Cell Differentiation Regulation Of Somitogenesis Regulation Of Neuron Differentiation Heart Looping Embryonic Heart Tube Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Kidney Epithelium Development Negative Regulation Of Neuron Differentiation Epithelium Development Regulation Of Inner Ear Auditory Receptor Cell Differentiation Axis Specification Regulation Of Embryonic Development Nephron Development Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Regulation Of Notch Signaling Pathway Negative Regulation Of Epidermal Cell Differentiation Regulation Of Cell Differentiation Blood Vessel Morphogenesis Notch Signaling Pathway Pulmonary Valve Morphogenesis Epithelial Tube Morphogenesis Morphogenesis Of An Epithelium Cell Differentiation Neuroendocrine Cell Differentiation	Positive Regulation Of Transcription By RNA Polymerase II E-box Binding Protein Dimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Macromolecule Metabolic Process DNA Binding Chromatin Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Muscle Cell Fate Commitment Positive Regulation Of Metabolic Process Cell Fate Commitment Sequence-specific Double-stranded DNA Binding Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development Regulation Of Gene Expression DNA-binding Transcription Factor Activity RNA Polymerase II Transcription Regulator Complex Regulation Of Skeletal Muscle Tissue Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Anterior/posterior Pattern Specification Regulation Of Striated Muscle Tissue Development Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Regulation Of Myotube Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of Metabolic Process Somitogenesis Animal Organ Development Cell Differentiation Regulation Of Macromolecule Metabolic Process Tissue Regeneration Segmentation Muscle Organ Development
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