LRRC8B and LRRC8D

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical)

		LRRC8B	LRRC8D
Description		leucine rich repeat containing 8 VRAC subunit B	leucine rich repeat containing 8 VRAC subunit D
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Monoatomic Ion Transport Aspartate Transmembrane Transport Monoatomic Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane	Intracellular Glucose Homeostasis Monoatomic Ion Transport Taurine Transmembrane Transport Aspartate Transmembrane Transport Protein Hexamerization Monoatomic Ion Transmembrane Transport Cellular Response To Osmotic Stress Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane
Pathways		Miscellaneous transport and binding events	Miscellaneous transport and binding events
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8	Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)	Cognitive function ( 25644384) Lung cancer ( 28604730) Mean platelet volume ( 32888494) Obsessive-compulsive symptoms ( 26859814) Squamous cell lung carcinoma ( 28604730) Thiopurine-induced digestive symptoms in inflammatory bowel disease ( 29923122)
Interacting Genes			2 interacting genes: APP EXOSC4
Entrez ID		23507	55144
HPRD ID		18145	11287
Ensembl ID		ENSG00000197147	ENSG00000171492
Uniprot IDs		A0A384N5V6 Q6P9F7	B3KRU1 Q7L1W4 Q96GG5
PDB IDs			6M04
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pyroptotic Inflammatory Response Cytolysis In Another Organism Cytolysis Cellular Response To Interleukin-1 Cellular Response To Type II Interferon Response To Interleukin-1 Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Killing Of Cells Of Another Organism Cellular Response To Lipopolysaccharide Positive Regulation Of Inflammatory Response Positive Regulation Of AIM2 Inflammasome Complex Assembly Cell Killing Cellular Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide GTPase Activity Defense Response To Bacterium Defense Response To Virus Taurine Transmembrane Transport Volume-sensitive Anion Channel Activity Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane Response To Molecule Of Bacterial Origin GTP Binding Guanine Nucleotide Transmembrane Transport Response To Virus Cyclic Nucleotide Transport Response To Bacterium Cellular Response To Cytokine Stimulus Regulation Of Inflammatory Response Protein Hexamerization Positive Regulation Of Defense Response Cellular Response To Lipid Response To Cytokine Aspartate Transmembrane Transport Response To Peptide Nucleotide Transmembrane Transport Innate Immune Response Golgi Membrane C4-dicarboxylate Transport Perinuclear Region Of Cytoplasm Protein Homodimerization Activity Defense Response To Protozoan Defense Response To Other Organism Response To Protozoan Molecular Function Inhibitor Activity Defense Response To Symbiont Purine Nucleotide Transport Adenine Nucleotide Transport Purine-containing Compound Transmembrane Transport	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Volume-sensitive Anion Channel Activity Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane Exoribonuclease Complex Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Guanine Nucleotide Transmembrane Transport Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Peptidase Activator Activity Cellular Response To Manganese Ion Cyclic Nucleotide Transport Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Regulation Of Growth Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle
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