LRRC8D

Description		leucine rich repeat containing 8 VRAC subunit D
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Intracellular Glucose Homeostasis Monoatomic Ion Transport Taurine Transmembrane Transport Aspartate Transmembrane Transport Protein Hexamerization Monoatomic Ion Transmembrane Transport Cellular Response To Osmotic Stress Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane
Pathways		Miscellaneous transport and binding events
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Cognitive function ( 25644384) Lung cancer ( 28604730) Mean platelet volume ( 32888494) Obsessive-compulsive symptoms ( 26859814) Squamous cell lung carcinoma ( 28604730) Thiopurine-induced digestive symptoms in inflammatory bowel disease ( 29923122)
Novel Interacting Genes		1 novel interacting genes: LRRC8B
Interacting Genes		2 interacting genes: APP EXOSC4
Entrez ID		55144
HPRD ID		11287
Ensembl ID		ENSG00000171492
Uniprot IDs		B3KRU1 Q7L1W4 Q96GG5
PDB IDs		6M04
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Volume-sensitive Anion Channel Activity Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane Exoribonuclease Complex Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Guanine Nucleotide Transmembrane Transport Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Peptidase Activator Activity Cellular Response To Manganese Ion Cyclic Nucleotide Transport Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Regulation Of Growth Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle
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