LEPROTL1 and LMBR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LEPROTL1	LMBR1
Description		leptin receptor overlapping transcript like 1	limb development membrane protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway	Signal Transduction Embryonic Digit Morphogenesis
Pathways
Drugs
Diseases			Acheiropodia Triphalangeal thumb, including: Triphalangeal thumb; Triphalangeal thumb-polysyndactyly syndrome Syndactyly
GWAS			Hip circumference adjusted for BMI ( 28552196) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Schizophrenia ( 26198764)
Interacting Genes		73 interacting genes: AGPAT4 ARL13B CD300C CD79A CISD2 CLDN7 CLEC2D CREB3L1 CYP4F2 EDA EHHADH ELOVL4 EMP1 FCER1G FFAR2 FMO1 GJA5 GJA8 GPR152 GPR42 GPX8 JPH1 KCNJ6 KLRG1 LMBR1 LMNA LNX1 LPAR3 LRRC4C MALL MSR1 NAT8 ORMDL3 PAQR8 PDZK1IP1 PEX16 PLP1 RBFA REEP4 REEP6 RNF5 RTP2 SCN3B SDCBP SFXN3 SLC16A2 SLC25A46 SLC30A4 SLC35H1 SLC71A2 SLC7A1 SMCO4 SPG21 SSMEM1 STING1 STX12 SYNDIG1 TGFA TMEM11 TMEM14B TMEM19 TMEM237 TMEM248 TMEM42 TMEM50A TMEM50B TMX2 TSNARE1 TSPAN2 TVP23A VAPA YIPF2 ZDHHC15	2 interacting genes: LEPROTL1 LMNA
Entrez ID		23484	64327
HPRD ID		09551	05700
Ensembl ID		ENSG00000104660	ENSG00000105983
Uniprot IDs		O95214 Q6FHL7	B7Z633 Q8WVP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Cellular Localization Myelination Axon Ensheathment SA Node Cell Action Potential Transmembrane Transport	Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament DNA Double-strand Break Attachment To Nuclear Envelope Ventricular Cardiac Muscle Cell Development Nuclear Pore Localization Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Mesenchymal Cell Proliferation Structural Constituent Of Nuclear Lamina Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Nuclear Lamina Protein Localization To Nuclear Envelope Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nuclear Envelope Organization Nuclear Migration Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Nucleus Localization Nuclear Lumen Negative Regulation Of Muscle Hypertrophy Cardiac Muscle Cell Development Intracellular Transport Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Regulation Of Release Of Cytochrome C From Mitochondria Cardiac Cell Development Multivesicular Body Sorting Pathway Negative Regulation Of Signal Transduction Striated Muscle Cell Development Cellular Localization Protein-containing Complex Localization Negative Regulation Of Cell Communication Regulation Of Cardiac Muscle Hypertrophy Establishment Of Localization In Cell Negative Regulation Of Signaling Cellular Senescence Chromosome Localization Nucleus Organization Identical Protein Binding Muscle Cell Development Structural Constituent Of Cytoskeleton Site Of Double-strand Break Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Telomere Maintenance Regulation Of Mitochondrion Organization Protein Import Into Nucleus Import Into Nucleus Muscle Organ Development
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