PES1 and BOP1

Number of citations of the paper that reports this interaction (PubMedID 39358380)
50

Data Source:
BioGRID (cross-linking study)
HPRD (two hybrid, in vitro)

		PES1	BOP1
Description		pescadillo ribosomal biogenesis factor 1	BOP1 ribosomal biogenesis factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Membrane Preribosome, Large Subunit Precursor PeBoW Complex	Nucleus Nucleoplasm Chromosome Nucleolus Preribosome, Large Subunit Precursor PeBoW Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Ribonucleoprotein Complex Binding	RNA Binding Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Cell Population Proliferation Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Cell Cycle	Ribosomal Large Subunit Assembly Cleavage In ITS2 Between 5.8S RRNA And LSU-rRNA Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Cell Population Proliferation Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Cell Cycle Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Gut microbiota relative abundance (Blautia) ( 33208821)	Dupuytren's disease ( 28886342) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Type 2 diabetes ( 30297969)
Interacting Genes		5 interacting genes: APP BOP1 CEBPA FILNC1 USP7	2 interacting genes: KLF10 PES1
Entrez ID		23481	23246
HPRD ID		05783	16558
Ensembl ID		ENSG00000100029	ENSG00000261236
Uniprot IDs		B2RDF2 B3KTZ6 F6VXF5 O00541	Q14137
PDB IDs		2EP8 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FLA 8FLB 8FLD 8FLE 8INE 8INF 8IPX 8IPY 8IR3	8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Developmental Maturation Axon Midline Choice Point Recognition Amylin Binding Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Protein Catabolic Process Protein-containing Complex Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Low-density Lipoprotein Particle Mediated Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Symbiont-mediated Disruption Of Host Cell PML Body	Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) PeBoW Complex Core Promoter Sequence-specific DNA Binding Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA Preribosome, Large Subunit Precursor
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