MED13L and MED13

Number of citations of the paper that reports this interaction (PMID 15175163)
80

Data Source:
HPRD (in vivo)

		MED13L	MED13
Gene Name		mediator complex subunit 13-like	mediator complex subunit 13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mediator Complex	Nucleus Nucleoplasm Membrane Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter	Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Colorectal cancer ( 21761138)
Protein-Protein Interactions		2 interactors: FBXW7 MED13	9 interactors: ESR1 FBXW7 MED12 MED13L MED23 MED29 MED4 MED9 SREBF1
Entrez ID		23389	9969
HPRD ID		10579	07229
Ensembl ID		ENSG00000123066	ENSG00000108510
Uniprot IDs		Q71F56	Q9UHV7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Cell Death Regulation Of DNA Endoreduplication Regulation Of Hepatocyte Proliferation Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ERBB Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Sister Chromatid Cohesion Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Regulation Of Triglyceride Metabolic Process Positive Regulation Of Protein Tyrosine Kinase Activity Androgen Receptor Signaling Pathway Positive Regulation Of Receptor Activity Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of Cellular Response To Oxidative Stress Regulation Of Lipid Storage Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To UV Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of Notch Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Positive Regulation Of Ligase Activity Negative Regulation Of Lipid Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Stabilization Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Light Stimulus Negative Regulation Of DNA Metabolic Process Vasculogenesis Lipid Homeostasis Regulation Of Receptor Activity Regulation Of DNA Replication Positive Regulation Of ERK1 And ERK2 Cascade	Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process DNA-templated Transcription, Initiation Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Triglyceride Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Organ Morphogenesis Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Triglyceride Metabolic Process Axis Elongation Tube Development Androgen Receptor Signaling Pathway Negative Regulation Of SREBP Signaling Pathway Cellular Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Prostate Epithelial Cord Elongation Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Developmental Growth Involved In Morphogenesis Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Axis Elongation Involved In Somitogenesis Negative Regulation Of DNA Endoreduplication Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process
Tagcloud ?		16p11 17q21 2p21 acot7 autism auts2 cask categorised cnvs crebbp ctnnd2 delineating exonic grm8 homozygous incidental instrumental iq kb microdeletion morbid ndds neurodevelopmental nrxn3 omim pafah1b1 satb2 sizing undiagnosed	accomplished arabidopsis cct cdk8 city coordinate delay developmental embryogenesis fine flc floral flowering gct germination gibberellic grand med12 mir156 module ontogeny operate phytohormone repressing repressors timing transitions tuning vegetative
Tagcloud (Difference) ?		16p11 17q21 2p21 acot7 autism auts2 cask categorised cnvs crebbp ctnnd2 delineating exonic grm8 homozygous incidental instrumental iq kb microdeletion morbid ndds neurodevelopmental nrxn3 omim pafah1b1 satb2 sizing undiagnosed	accomplished arabidopsis cct cdk8 city coordinate delay developmental embryogenesis fine flc floral flowering gct germination gibberellic grand med12 mir156 module ontogeny operate phytohormone repressing repressors timing transitions tuning vegetative
Tagcloud (Intersection) ?