KHNYN and HECTD1

		KHNYN	HECTD1
Description		KH and NYN domain containing	HECT domain E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Cellular_component Nucleus Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Molecular_function RNA Binding MRNA Binding RNA Endonuclease Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Biological_process	Heart Valve Development Ventricular Septum Development Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)
Interacting Genes		5 interacting genes: CUL1 CUL2 PLOD3 TEPSIN UBC	9 interacting genes: HRAS IGSF1 MTNR1B NRIP1 UBE2D1 UBE2D2 UBE2D3 UBE2L3 YWHAG
Entrez ID		23351	25831
HPRD ID		11076	17098
Ensembl ID		ENSG00000100441	ENSG00000092148
Uniprot IDs		A8K6L5 O15037	A0A087X2H1 A0A8I5QJU2 H0YJD4 Q9ULT8
PDB IDs		2N5M 2N7K 8WZC 9BGL 9CS9 9HTS	2DK3 2LC3 3DKM
Enriched GO Terms of Interacting Partners?		Ubiquitin Ligase Complex Scaffold Activity Modification-dependent Protein Catabolic Process Cullin-RING Ubiquitin Ligase Complex Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Proteolysis Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Coated Vesicle Membrane Ubiquitin-dependent Protein Catabolic Process Hydroxylysine Biosynthetic Process Protein Metabolic Process Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Procollagen Glucosyltransferase Activity Procollagen-lysine 5-dioxygenase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Basement Membrane Assembly Procollagen Galactosyltransferase Activity Intrinsic Apoptotic Signaling Pathway Catabolic Process Epidermis Morphogenesis Protein-macromolecule Adaptor Activity Peptidyl-lysine Hydroxylation Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Endothelial Cell Morphogenesis Apoptotic Signaling Pathway Protein Tag Activity Protein Hydroxylation Cul2-RING Ubiquitin Ligase Complex L-ascorbic Acid Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Apoptotic Process Macromolecule Metabolic Process Small Molecule Binding Heart Valve Development	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein K6-linked Ubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Macromolecule Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteolysis Ovarian Follicle Rupture Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Signal Transduction GTPase Complex Activin Receptor Antagonist Activity Ubiquitin Protein Ligase Activity TOR Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Phospholipase C Activator Activity Protein Kinase C Inhibitor Activity Positive Regulation Of Protein Ubiquitination Protein Modification Process Regulation Of BMP Signaling Pathway Inhibin Binding Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Nucleotide Binding Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Regulation Of Neuronal Action Potential
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