VPS39 and NUSAP1

		VPS39	NUSAP1
Description		VPS39 subunit of HOPS complex	nucleolar and spindle associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex HOPS Complex Late Endosome Membrane Lysosomal HOPS Complex	Nucleus Chromosome Nucleolus Cytoplasm Spindle Cytoskeleton Microtubule Mitotic Spindle
	Molecular Function	Protein Binding	DNA Binding RNA Binding Protein Binding Microtubule Binding
	Biological Process	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Endocytic Recycling Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Autophagosome-lysosome Fusion Late Endosome To Lysosome Transport	Mitotic Sister Chromatid Segregation Microtubule Cytoskeleton Organization Mitotic Cytokinesis Mitotic Chromosome Condensation Establishment Of Mitotic Spindle Localization Positive Regulation Of Mitotic Nuclear Division Cell Division
Pathways		SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Ulcerative colitis ( 23128233 28067908)
Interacting Genes		7 interacting genes: HOOK1 MECOM RILP RUNX1 SNW1 STAT3 TFIP11	4 interacting genes: APP CEBPA CEP70 OGT
Entrez ID		23339	51203
HPRD ID		10300	14857
Ensembl ID		ENSG00000166887	ENSG00000137804
Uniprot IDs		Q96JC1	Q9BXS6
PDB IDs		6ZE9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Extracellular Matrix Organization Hematopoietic Stem Cell Proliferation Nuclear Speck Early Endosome To Late Endosome Transport Dynein Light Intermediate Chain Binding Negative Regulation Of DNA-templated Transcription Protein Homodimerization Activity Negative Regulation Of RNA Biosynthetic Process Endosome To Lysosome Transport Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Biosynthetic Process Core-binding Factor Complex Negative Regulation Of Transcription By RNA Polymerase II Stem Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Pericentric Heterochromatin Organization CENP-A Recruiting Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Endosome Organization Intralumenal Vesicle Formation Cardiac Muscle Tissue Regeneration Nucleoplasm RNA Sequestering Activity Maintenance Of Cell Number Stem Cell Population Maintenance Lysosomal Transport Positive Regulation Of Vasculature Development Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Angiogenesis Regulation Of Macromolecule Metabolic Process Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation DNA-binding Transcription Factor Binding DNA Binding Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Metabolic Process Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3K9me2 Methyltransferase Activity	Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Chromatin DNA Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Synapse Assembly Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chemical Homeostasis Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Developmental Maturation Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Hemopoiesis Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Cell Development Protein-containing Complex Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion
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