KAZN and TNS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KAZN	TNS4
Description		kazrin, periplakin interacting protein	tensin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Nuclear Speck Desmosome Anchoring Junction	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Anchoring Junction
	Molecular Function	Protein Binding	Actin Binding Protein Binding
	Biological Process	Keratinization	Intracellular Protein Localization
Pathways		Formation of the cornified envelope	MET interacts with TNS proteins
Drugs
Diseases
GWAS		Body mass index ( 28552196) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronic pain ( 33685280) Chronotype ( 30696823) Conotruncal heart defects (inherited effects) ( 28468790) Copper levels ( 26025379) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels in HIV infection ( 33109212) Lean body mass ( 28552196) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Mercury levels ( 26025379) Moderate-to-late spontaneous preterm birth ( 31194736) Non-response to antidepressants and depression ( 27622933) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Schizophrenia x sex interaction ( 34099189) Triacylglyceride levels ( 31551469) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Weight ( 28552196)	Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)
Interacting Genes		14 interacting genes: ARID5A CLVS2 COIL DVL3 FXR1 LMO2 LZTS1 LZTS2 PPL PSMA1 TNS4 TSC1 TXN2 USP2	23 interacting genes: AR CARD9 CYSRT1 EGFR ERBB3 ERBB4 GAB1 GSTCD HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1
Entrez ID		23254	84951
HPRD ID		11122	12223
Ensembl ID		ENSG00000189337	ENSG00000131746
Uniprot IDs		Q674X7	Q6PJP3 Q8IZW8
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process ErbB-3 Class Receptor Binding Positive Regulation Of Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Eyelid Development In Camera-type Eye Receptor Complex Morphogenesis Of An Epithelial Fold Kinase Activity Negative Regulation Of Programmed Cell Death ATPase Binding Protein Tyrosine Kinase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Viral Transcription Mammary Gland Alveolus Development Suppression Of Viral Release By Host Regulation Of MiRNA Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Positive Regulation Of Metabolic Process Regulation Of Cell Communication Positive Regulation Of Multicellular Organismal Process
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