KIN and IL2RA

		KIN	IL2RA
Description		Kin17 DNA and RNA binding protein	interleukin 2 receptor subunit alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Protein-containing Complex	Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding
	Biological Process	DNA Replication DNA Repair DNA Recombination MRNA Processing DNA Damage Response	Immune System Process Inflammatory Response To Antigenic Stimulus Regulation Of T Cell Tolerance Induction Regulation Of Immune System Process Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Lymphocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Protein methylation	RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Basiliximab Daclizumab Inolimomab Camidanlumab tesirine
Diseases			Type I diabetes mellitus T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Asthma ( 31959851) Mean reticulocyte volume ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Alopecia areata ( 20596022 25608926) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634 31959851 31619474 31361310 30929738 32296059) Asthma (adult onset) ( 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 30929738) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diisocyanate-induced asthma ( 25918132) Eczema ( 31361310) Emotional dysregulation ( 27643478) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Graves' disease ( 22922229) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Interleukin-2 receptor antagonist levels ( 27989323) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 19525953 17660530 19525955 21833088 28445677 24076602 22190364 27386562) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Plasma t-tau levels ( 28100725) Primary sclerosing cholangitis ( 27992413 23603763) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 30572963 30423114 24449572 24390342 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 30572963 25751624 22293688 21829393 19430480 18978792) Vitiligo ( 27723757 20410501) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: MIR1-1 MIR363	8 interacting genes: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B
Entrez ID		22944	3559
HPRD ID		03425	00986
Ensembl ID		ENSG00000151657	ENSG00000134460
Uniprot IDs		O60870	H0Y5Z0 P01589 Q5W005
PDB IDs		2CKK 2V1N 7ABH 7ABI 8I0P 9COJ	1Z92 2B5I 2ERJ 3IU3 3NFP 6VWU 6YIO 7F9W 7ZMZ
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Homeostatic Proliferation Interleukin-2 Receptor Complex Interleukin-2 Binding Interleukin-2 Receptor Activity Regulatory NcRNA-mediated Gene Silencing Reversible Differentiation Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Phenotypic Switching Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Cardiac Conduction Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Mesoderm Formation Positive Regulation Of Mesoderm Development Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cell Migration Involved In Vasculogenesis Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Positive Regulation Of Sarcomere Organization Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Activation-induced Cell Death Of T Cells Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Mesoderm Development Activated T Cell Proliferation Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Cardiac Muscle Contraction Regulation Of Response To Drug Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Sarcomere Organization Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Interleukin-2-mediated Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of T Cell Tolerance Induction Positive Regulation Of Cell Fate Commitment Positive Regulation Of Myotube Differentiation Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Cardiocyte Differentiation Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Binding Cytokine-mediated Signaling Pathway Response To Peptide Response To Cytokine Positive Regulation Of Inflammatory Response Cellular Response To Interleukin-17 Activated T Cell Proliferation Cellular Response To Cytokine Stimulus Regulation Of Vitamin Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Immune Response Progesterone Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Alcohol Regulation Of Monoatomic Cation Transmembrane Transport Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cell Population Proliferation Response To Estradiol Positive Regulation Of T Cell Proliferation Adaptive Immune Response Positive Regulation Of Myeloid Cell Differentiation T Cell Activation Positive Regulation Of B Cell Differentiation Transcription By RNA Polymerase II Negative Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Response To Ethanol Growth Hormone Receptor Signaling Pathway C21-steroid Hormone Metabolic Process Regulation Of Metal Ion Transport Sex Differentiation Positive Regulation Of Activated T Cell Proliferation Cellular Response To Hormone Stimulus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation Regulation Of Transport Sodium Channel Regulator Activity Immune Effector Process Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Interleukin-2 Production Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Inflammatory Response
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