SLITRK3 and IFT80

Data Source: HiPPIP (Novel)

		SLITRK3	IFT80
Name		SLIT and NTRK like family member 3	intraflagellar transport 80
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Postsynaptic Membrane Postsynaptic Density Membrane GABA-ergic Synapse Postsynaptic Specialization Membrane	Cytoplasm Centrosome Cytoskeleton Cilium Intraciliary Transport Particle B Ciliary Basal Body Cell Projection Ciliary Tip 9+0 Non-motile Cilium
	Molecular Function	Protein Binding	None
	Biological Process	Axonogenesis Synaptic Transmission, GABAergic Positive Regulation Of Synapse Assembly Terminal Button Organization Neurotransmitter-gated Ion Channel Clustering Postsynaptic Density Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Apoptotic Process Establishment Or Maintenance Of Cell Polarity Smoothened Signaling Pathway Canonical NF-kappaB Signal Transduction Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Tissue Development Gene Expression Proteasomal Protein Catabolic Process Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Spinal Cord Development Osteoclast Differentiation Osteoblast Proliferation Multicellular Organism Growth Non-canonical Wnt Signaling Pathway Bone Mineralization Involved In Bone Maturation Intraciliary Anterograde Transport Odontogenesis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Keratinocyte Proliferation Tooth Eruption Cilium Organization Stem Cell Differentiation Protein Stabilization Cartilage Development Limb Development Cilium Assembly Bone Development Bone Morphogenesis Articular Cartilage Development Odontoblast Differentiation Stem Cell Proliferation Receptor Localization To Non-motile Cilium Response To Inositol Non-motile Cilium Assembly Cartilage Homeostasis Negative Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		Receptor-type tyrosine-protein phosphatases RAC3 GTPase cycle	Intraflagellar transport Intraflagellar transport
GWAS		Blood protein levels ( 30072576 ) Metabolite levels ( 23823483 )	Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Bipolar disorder ( 31043756 ) LDL cholesterol ( 30275531 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Malaria ( 31844061 )
Novel Interactors		1 novel interactors: IFT80	5 novel interactors: FGFR4 NMD3 OTOL1 SLITRK3 ZBBX
Interacting Genes		1 interacting genes: TRIM54	2 interacting genes: PLXNA2 UBXN10
Entrez ID		22865	57560
HPRD ID		18064	13853
Ensembl ID		ENSG00000121871	ENSG00000068885
Uniprot IDs		O94933	Q9P2H3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Tooth Eruption Articular Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Negative Regulation Of Non-canonical Wnt Signaling Pathway Bone Mineralization Involved In Bone Maturation Response To Inositol Cartilage Homeostasis Receptor Localization To Non-motile Cilium Odontoblast Differentiation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Protein Localization To Ciliary Membrane Protein Localization To Non-motile Cilium Growth Plate Cartilage Development 9+0 Non-motile Cilium Osteoblast Proliferation Microtubule-based Process Intraciliary Transport Particle B Intraciliary Anterograde Transport Cartilage Development Involved In Endochondral Bone Morphogenesis Negative Regulation Of Keratinocyte Proliferation Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Microtubule Depolymerization Spinal Cord Development Endochondral Ossification Keratinocyte Proliferation Regulation Of Microtubule Depolymerization Microtubule Associated Complex Neuroepithelial Cell Differentiation Bone Morphogenesis Negative Regulation Of Microtubule Polymerization Or Depolymerization Ciliary Tip Regulation Of Keratinocyte Proliferation Osteoclast Differentiation Intraciliary Transport Non-motile Cilium Assembly Limb Development Non-canonical Wnt Signaling Pathway Cytoskeleton Chondrocyte Differentiation Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Protein Localization To Cilium Canonical NF-kappaB Signal Transduction Connective Tissue Development Bone Development Negative Regulation Of Protein-containing Complex Disassembly Stem Cell Proliferation Regulation Of Protein Depolymerization Smoothened Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	None