ZNF25 and SCRN1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZNF25	SCRN1
Name		zinc finger protein 25	secernin 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Nuclear Membrane Presynapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Dipeptidase Activity Cysteine-type Exopeptidase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Proteolysis Exocytosis Regulation Of Synaptic Vesicle Cycle
Pathways		Generic Transcription Pathway	None
GWAS		Extrinsic epigenetic age acceleration ( 29374233 )	Obesity-related traits ( 23251661 ) Psoriasis ( 25854761 )
Novel Interactors		1 novel interactors: CUL2	1 novel interactors: NPC2
Interacting Genes		3 interacting genes: ADRB2 LMNA SCRN1	4 interacting genes: GORASP1 HGS OGT ZNF25
Entrez ID		219749	9805
HPRD ID		01916	15304
Ensembl ID		ENSG00000175395	ENSG00000136193
Uniprot IDs		P17030	A0A090N7T9 Q12765
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Nuclear Lumen Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Pore Localization Structural Constituent Of Nuclear Lamina Cysteine-type Exopeptidase Activity Regulation Of Muscle System Process Nuclear Membrane Positive Regulation Of Autophagosome Maturation Heat Generation Negative Regulation Of Mesenchymal Cell Proliferation Ubiquitin Ligase Complex Scaffold Activity Adrenergic Receptor Activity Diet Induced Thermogenesis Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Dipeptidase Activity Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Nuclear Lamina Protein Localization To Nuclear Envelope Cullin-RING Ubiquitin Ligase Complex Regulation Of Synaptic Vesicle Cycle Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Release Of Cytochrome C From Mitochondria Cul2-RING Ubiquitin Ligase Complex Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Adaptive Thermogenesis Nuclear Envelope Organization Bone Resorption Regulation Of System Process Nuclear Migration	Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Vacuole Negative Regulation Of Developmental Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Glycoprotein Biosynthetic Process Positive Regulation Of Transcription By Glucose Macroautophagy Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity ESCRT-0 Complex Phagocytic Vesicle Lumen Cholesterol Storage Sterol Binding Regulation Of Isoprenoid Metabolic Process Carbon Catabolite Regulation Of Transcription Glycoprotein Metabolic Process Glycolipid Transport Autophagy Regulation Of Transcription By Glucose Negative Regulation Of Multicellular Organismal Process Golgi Ribbon Formation Negative Regulation Of Dendrite Morphogenesis NSL Complex Regulation Of Lipid Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway