UNC5B and FLRT3

Number of citations of the paper that reports this interaction (PubMedID 21673655)
40

Data Source:
BioGRID (pull down, pull down)

		UNC5B	FLRT3
Description		unc-5 netrin receptor B	fibronectin leucine rich transmembrane protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Membrane Raft	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Cell Junction Axon Extracellular Matrix Growth Cone Membrane Presynaptic Membrane Cell Projection Axon Terminus Axonal Growth Cone Synapse Postsynaptic Membrane Anchoring Junction Synaptic Membrane Glutamatergic Synapse
	Molecular Function	Netrin Receptor Activity Protein Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Protein Homodimerization Activity Chemorepellent Activity
	Biological Process	Angiogenesis Apoptotic Process Signal Transduction Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Proepicardium Cell Migration Involved In Pericardium Morphogenesis Cell Adhesion Axon Guidance Synapse Assembly Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Neuron Projection Development Embryonic Morphogenesis Response To Axon Injury Negative Chemotaxis Positive Regulation Of Synapse Assembly Head Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Synaptic Membrane Adhesion Neuron Projection Extension
Pathways		Netrin-1 signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand	Signaling by ROBO receptors Downstream signaling of activated FGFR1
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 33772158) Diisocyanate-induced asthma ( 25918132) Problematic alcohol use ( 32451486) Vitiligo ( 22951725)	Bipolar disorder ( 33169155) Blood protein levels ( 30072576) Mood disorder in prion disease ( 25897833)
Interacting Genes		4 interacting genes: DAPK1 FLRT3 PPP2R1B TREM2	2 interacting genes: FGFR1 UNC5B
Entrez ID		219699	23767
HPRD ID		08487	05313
Ensembl ID		ENSG00000107731	ENSG00000125848
Uniprot IDs		Q8IZJ1	Q9NZU0
PDB IDs			5CMN 5CMP 6JBU
Enriched GO Terms of Interacting Partners?		DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Response To Axon Injury Proepicardium Cell Migration Involved In Pericardium Morphogenesis Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of Complement Activation, Classical Pathway Detection Of Lipoteichoic Acid Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Regulation Of Toll-like Receptor 6 Signaling Pathway Regulation Of NMDA Receptor Activity Meiotic Sister Chromatid Cohesion, Centromeric Response To Wounding Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Macrophage Fusion Sulfatide Binding Negative Regulation Of Astrocyte Activation CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of Fat Cell Proliferation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of CD40 Signaling Pathway Positive Regulation Of CAMKK-AMPK Signaling Cascade Respiratory Burst After Phagocytosis Negative Regulation Of Autophagic Cell Death Positive Regulation Of Complement Activation Detection Of Lipopolysaccharide Complement-mediated Synapse Pruning Positive Regulation Of Microglial Cell Migration Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Apolipoprotein A-I Binding Positive Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Regulation Of CAMKK-AMPK Signaling Cascade Microglial Cell Activation Involved In Immune Response Regulation Of Astrocyte Activation Very-low-density Lipoprotein Particle Binding Positive Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Hippocampal Neuron Apoptotic Process Detection Of Peptidoglycan Negative Regulation Of Triglyceride Storage Lipoteichoic Acid Binding Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Growth Cone Membrane Synapse Organization Positive Regulation Of Microglial Cell Activation Lipoprotein Particle Binding	Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Vitamin D3 Metabolic Process Lung-associated Mesenchyme Development Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Branching Involved In Salivary Gland Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Mitotic Cell Cycle DNA Replication Outer Ear Morphogenesis Positive Regulation Of Lipase Activity Receptor-receptor Interaction Ventricular Zone Neuroblast Division Regulation Of Mesodermal Cell Differentiation Mesenchymal-epithelial Cell Signaling Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cementum Mineralization Diphosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fibroblast Growth Factor Receptor Activity Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Auditory Receptor Cell Development Orbitofrontal Cortex Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Fibroblast Growth Factor Production Angiogenesis Paraxial Mesoderm Development Response To Sodium Phosphate Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Phospholipase Activity Regulation Of Phosphate Transport Forebrain Neuroblast Division Regulation Of Lateral Mesodermal Cell Fate Specification Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Parathyroid Hormone Secretion Netrin-activated Signaling Pathway Anterior/posterior Axon Guidance Netrin Receptor Activity Salivary Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Regulation Of Nuclear Cell Cycle DNA Replication Neuron Projection Development Vitamin D Metabolic Process Inner Ear Receptor Cell Development Ear Development T-helper 17 Cell Lineage Commitment Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of DNA-templated DNA Replication Positive Regulation Of Interleukin-13 Production Regulation Of Postsynaptic Density Assembly
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