GSX1 and PAN3

		GSX1	PAN3
Description		GS homeobox 1	poly(A) specific ribonuclease subunit PAN3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	P-body Nucleus Cytoplasm Cytosol PAN Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding RNA Binding Poly(A)-specific Ribonuclease Activity Protein Kinase Activity Protein Binding ATP Binding Poly(A) Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Central Nervous System Development Brain Development Spinal Cord Association Neuron Differentiation Hypothalamus Development Adenohypophysis Development Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Processing Protein Targeting Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly
Pathways			Deadenylation of mRNA
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Alanine aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Body mass index ( 26426971) Pancreatic cancer ( 25086665) Plasma parathyroid hormone levels ( 30134803)	Bipolar disorder ( 20351715) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Hepcidin/transferrin saturation ratio ( 27846281) Mean corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Pancreatic cancer ( 25086665)
Interacting Genes		1 interacting genes: KRTAP19-7	5 interacting genes: PABPC1 PAN2 RNF10 SVIL TNRC6B
Entrez ID		219409	255967
HPRD ID		11016	17818
Ensembl ID		ENSG00000169840	ENSG00000152520
Uniprot IDs		Q9H4S2	Q58A45
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA Methylguanosine-cap Decapping Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Poly(A)-specific Ribonuclease Activity PAN Complex Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Poly(A) Binding Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Decapping	Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process P-body PAN Complex Mitochondrial Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Catabolic Process Nucleic Acid Binding Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Post-transcriptional Regulation Of Gene Expression MCRD-mediated MRNA Stability Complex Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Microtubule Minus-end RNA Catabolic Process Negative Regulation Of Schwann Cell Proliferation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Adenohypophysis Development CRD-mediated MRNA Stabilization Spinal Cord Association Neuron Differentiation Poly(A)-specific Ribonuclease Activity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Actin Filament Severing Translation Activator Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Hypothalamus Development
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