SENP5 and RABGAP1

Number of citations of the paper that reports this interaction (PubMedID 16608850)
0

Data Source:
BioGRID (enzymatic study)

		SENP5	RABGAP1
Description		SUMO specific peptidase 5	RAB GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Presynaptic Cytosol Postsynaptic Cytosol	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Associated Complex
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity	GTPase Activator Activity Protein Binding Tubulin Binding Small GTPase Binding
	Biological Process	Proteolysis Protein Sumoylation Protein Desumoylation Cell Division	Regulation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		SUMO is proteolytically processed	TBC/RABGAPs
Drugs
Diseases
GWAS		Gestational age at birth (child effect) ( 31194736) Malaria ( 31844061) Night sleep phenotypes ( 27126917)	Birth weight ( 31043758) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878)
Interacting Genes		3 interacting genes: RABGAP1 SUMO2 SUMO3	10 interacting genes: CARM1 DISC1 GABARAPL1 MAP1LC3A RAB4A RAB6A RAB6B SENP1 SENP5 STAT3
Entrez ID		205564	23637
HPRD ID		10222	06575
Ensembl ID		ENSG00000119231	ENSG00000011454
Uniprot IDs		B2R9F5 Q96HI0	B7Z2B4 Q9Y3P9
PDB IDs			4NC6
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Ubiquitin-like Protein Ligase Binding Protein Sumoylation PML Body Negative Regulation Of DNA Binding SUMO Transferase Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Regulation Of DNA Binding Post-translational Protein Modification Hippocampal Mossy Fiber To CA3 Synapse Microtubule Associated Complex	Glutamatergic Synapse Protein Localization To Golgi Membrane Cellular Response To Nitrogen Starvation SUMO-specific Endopeptidase Activity Protein Desumoylation DeSUMOylase Activity Ciliary Basal Body Phosphatidylethanolamine Binding Myosin V Binding Protein Localization To Golgi Apparatus Presynaptic Cytosol Postsynaptic Cytosol Intra-Golgi Vesicle-mediated Transport Protein Localization To Organelle Endomembrane System Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Regulation Of Erythrocyte Differentiation Autophagosome Maturation Protein Sumoylation Autophagosome Membrane Mitophagy Peptidyl-cysteine Methylation GTPase Activity Microtubule Autophagy Of Mitochondrion Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome GTP Binding Cytoplasmic Vesicle Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Histone H3R2 Methyltransferase Activity Histone H3R17 Methyltransferase Activity Autophagosome Hydrolase Activity Antigen Processing And Presentation Retrograde Transport, Endosome To Golgi Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Histone Arginine N-methyltransferase Activity Autophagosome Organization Autophagosome Assembly Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of Definitive Erythrocyte Differentiation Intracellular Protein Localization Positive Regulation Of MRNA Catabolic Process Protein Modification By Small Protein Removal Phospholipid Binding Minus-end-directed Organelle Transport Along Microtubule
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