SLC44A5 and NEGR1

		SLC44A5	NEGR1
Description		solute carrier family 44 member 5	neuronal growth regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Plasma Membrane Postsynaptic Density Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Apical Dendrite Side Of Membrane
	Molecular Function	Protein Binding Choline Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity	Protein Binding
	Biological Process	Phosphatidylcholine Biosynthetic Process Choline Transport Transmembrane Transport	Cell Adhesion Brain Development Locomotory Behavior Feeding Behavior Positive Regulation Of Neuron Projection Development Neuron Projection Development Social Behavior Cholesterol Homeostasis Fat Cell Differentiation Positive Regulation Of Saliva Secretion Neuron Projection Morphogenesis Positive Regulation Of Calcium-mediated Signaling Regulation Of Synapse Assembly Negative Regulation Of Synapse Assembly Negative Regulation Of Glial Cell Proliferation Skeletal Muscle Organ Development Cell-cell Adhesion Lipid Droplet Formation
Pathways		Synthesis of PC SLC-mediated bile acid transport	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Capecitabine sensitivity ( 22864933) Self-reported tiredness ( 28194004) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption (drinks per week) ( 30643258) Allergic rhinitis ( 30013184) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 29273806) Asthma and major depressive disorder ( 31619474) Beef consumption ( 32066663) Bipolar disorder or body mass index ( 31754094) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body composition traits ( 30026463) Body mass index ( 26961502 28892062 28448500 19079261 26426971 31888951 25673413 23563607 19079260 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Broad depression or major depressive disorder (self-reported) ( 30626913) Cervical high-risk human papilloma virus infection ( 33225922) Childhood body mass index ( 26604143 33045005) Chromium levels ( 26025379) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Diffusing capacity of carbon monoxide ( 30694715) Experiencing mood swings ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heel bone mineral density ( 30598549) Hemostatic factors and hematological phenotypes ( 17903294) Hip circumference ( 25673412) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Meat-related diet ( 32066663) Menarche (age at onset) ( 25231870) Mental health study participation (completed survey) ( 31263887) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity ( 23563607) Obesity (early onset extreme) ( 23563609) Obesity (extreme) ( 30677029 31888951) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Rosacea symptom severity ( 29771307) Self-reported risk-taking behaviour ( 30271922) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Subcutaneous adipose tissue ( 22589738) Systemic lupus erythematosus ( 18204098) Urinary sodium excretion ( 31409800) Venlafaxine response in generalised anxiety disorder (HAMA-A score reduction after 24 weeks) ( 28437668) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		1 interacting genes: CFTR	2 interacting genes: LSAMP NTM
Entrez ID		204962	257194
HPRD ID		14580	14820
Ensembl ID		ENSG00000137968	ENSG00000172260
Uniprot IDs		B7Z5Y4 Q8NCS7	Q7Z3B1
PDB IDs			6DLD 6U6T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Secretion Positive Regulation Of Anion Channel Activity Regulation Of Body Fluid Levels Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Saliva Secretion Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Saliva Secretion Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Negative Regulation Of Synapse Assembly Regulation Of Secretion Positive Regulation Of Digestive System Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Negative Regulation Of Synapse Organization Apical Dendrite Lipid Droplet Formation Response To Forskolin Negative Regulation Of Glial Cell Proliferation Chloride Transmembrane Transporter Activity Sperm Capacitation Positive Regulation Of Transport Skeletal Muscle Organ Development Chemical Homeostasis Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Vesicle Docking Involved In Exocytosis Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Positive Regulation Of Transporter Activity Sterol Biosynthetic Process ABC-type Transporter Activity Transepithelial Transport	Side Of Membrane Choline Transmembrane Transporter Activity Choline Transport
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