ADAM32 and CLDN8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADAM32	CLDN8
Description		ADAM metallopeptidase domain 32	claudin 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Anchoring Junction
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Cell Adhesion Binding Of Sperm To Zona Pellucida Male Gonad Development	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly
Pathways			Tight junction interactions
Drugs
Diseases
GWAS		Herpes simplex virus 2 mgG-1 antibody levels ( 33204752)	Response to statin therapy ( 20339536)
Interacting Genes		1 interacting genes: CLDN8	12 interacting genes: ADAM32 ARL13B CLEC17A ERGIC3 KASH5 OPRM1 PKMYT1 SMIM3 SYNE4 TJP1 TMEM80 TRARG1
Entrez ID		203102	9073
HPRD ID		16475	10835
Ensembl ID		ENSG00000197140	ENSG00000156284
Uniprot IDs		A0A140VJD9 B4DTC2 Q8TC27	A0A0K0K1I9 P56748
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion Monocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Keratinocyte Migration Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Laminin Binding Cell Adhesion Response To Manganese Ion Amyloid Precursor Protein Metabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Macrophage Fusion Amyloid Precursor Protein Catabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Cell-cell Adhesion Mediated By Integrin Apicolateral Plasma Membrane Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Mediated By Integrin Membrane Protein Proteolysis Positive Regulation Of Epithelial Cell Migration Protein Kinase C Binding Regulation Of Cell Adhesion Mediated By Integrin Bicellular Tight Junction Assembly Tight Junction Assembly Tight Junction Organization Collagen Binding Keratinocyte Differentiation Regulation Of Epithelial Cell Migration	Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Nuclear Outer Membrane
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