HTRA4 and ADAM9

		HTRA4	ADAM9
Description		HtrA serine peptidase 4	ADAM metallopeptidase domain 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Laminin Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Proteolysis Programmed Cell Death Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process	Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Cell Migration Protein Processing Keratinocyte Differentiation Positive Regulation Of Cell Migration Membrane Protein Intracellular Domain Proteolysis Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Monocyte Activation Response To Hydrogen Peroxide Amyloid Precursor Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide
Pathways			Collagen degradation
Drugs			INCB7839
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS			Basophil count ( 32888494)
Interacting Genes		1 interacting genes: GTF2IRD1	10 interacting genes: DYRK1A ITGA3 ITGA6 ITGAV MAD2L2 PRKCD SH3D19 SH3GLB1 SNX9 TNF
Entrez ID		203100	8754
HPRD ID		08818	04091
Ensembl ID		ENSG00000169495	ENSG00000168615
Uniprot IDs		P83105	Q13443
PDB IDs
Enriched GO Terms of Interacting Partners?		Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Macrophage Fusion Transition Between Slow And Fast Fiber Monocyte Activation Positive Regulation Of Keratinocyte Migration Response To Manganese Ion Membrane Protein Intracellular Domain Proteolysis Cell-cell Adhesion Mediated By Integrin Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Laminin Binding Amyloid Precursor Protein Metabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Cell Adhesion Mediated By Integrin Membrane Protein Proteolysis Positive Regulation Of Epithelial Cell Migration Protein Kinase C Binding Regulation Of Cell Adhesion Mediated By Integrin	Positive Regulation Of Membrane Protein Ectodomain Proteolysis Integrin Complex Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Neuregulin Binding Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Regulation Of Amide Metabolic Process Cell-cell Adhesion Cell Adhesion Regulation Of Catalytic Activity Insulin-like Growth Factor I Binding Positive Regulation Of Catabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Cell-matrix Adhesion Protease Binding Filopodium Membrane Positive Regulation Of Phosphate Metabolic Process Cell Surface Regulation Of Membrane Lipid Metabolic Process Negative Regulation Of Lipid Storage Negative Regulation Of Cellular Component Organization Regulation Of Protein Catabolic Process Regulation Of Organelle Organization Regulation Of Apoptotic Signaling Pathway Cell-substrate Adhesion Anchoring Junction Fibronectin Binding Positive Regulation Of Amide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Adhesion Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid-beta Formation Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Metabolic Process Histone H3T45 Kinase Activity Leukocyte Migration Positive Regulation Of Apoptotic Process Cell Migration Integrin Alpha6-beta4 Complex Regulation Of Lipid Storage Entry Into Host Cell By A Symbiont-containing Vacuole Opsonin Binding Positive Regulation Of Phospholipid Scramblase Activity
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