TSNARE1 and TOP1MT

		TSNARE1	TOP1MT
Description		t-SNARE domain containing 1	DNA topoisomerase I mitochondrial
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Endomembrane System Membrane SNARE Complex	Nucleus Nucleoplasm Chromosome Mitochondrion Mitochondrial Nucleoid
	Molecular Function	SNARE Binding SNAP Receptor Activity	DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Isomerase Activity
	Biological Process	Intracellular Protein Transport Vesicle Fusion Vesicle-mediated Transport Vesicle Docking	DNA Replication DNA Topological Change
Pathways
Drugs			Irinotecan Topotecan
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder x sex interaction ( 34099189) Body size at age 10 ( 32376654) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling nervous ( 29500382) Feeling tense ( 29500382) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Intelligence (MTAG) ( 29326435) Mental health study participation (completed survey) ( 31263887) Monoclonal gammopathy of undetermined significance ( 30737484) Schizophrenia ( 25056061 28991256 29483656 23974872 30285260) Systolic blood pressure ( 30578418 30224653)	Height ( 31562340) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		27 interacting genes: AQP6 CD79A CNIH4 CYB561 DYNLL1 EBP ELOVL4 ELOVL5 GPR152 JAGN1 LEPROTL1 LMNA REEP4 RETREG3 SEC11C SLC10A6 SLC35H1 SLC71A2 STX1A TM4SF19 TMEM229B TMEM51 TMEM86B TMX2 VEZT YIPF4 ZDHHC15	2 interacting genes: TP53 UBC
Entrez ID		203062	116447
HPRD ID		08708	16214
Ensembl ID		ENSG00000171045	ENSG00000184428
Uniprot IDs		A0AVG3 E5RHT3 Q6P186 Q96NA8	B4DYD2 E5KMK7 Q969P6
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Endoplasmic Reticulum Organization Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Long-chain Fatty-acyl-CoA Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Nuclear Envelope Organization Long-chain Fatty-acyl-CoA Metabolic Process Myosin Binding Fatty-acyl-CoA Biosynthetic Process	Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity Ubiquitin Protein Ligase Binding B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Regulation Of Thymocyte Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of ATP-dependent Activity ER Overload Response Mitotic G1 DNA Damage Checkpoint Signaling MDM2/MDM4 Family Protein Binding TFIID-class Transcription Factor Complex Binding Lactate Metabolic Process Replicative Senescence Positive Regulation Of Programmed Necrotic Cell Death Type II Interferon-mediated Signaling Pathway Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Mitotic G1/S Transition Checkpoint Signaling Cellular Response To Antibiotic Negative Regulation Of Mitophagy Necroptotic Process Intracellular Protein Transport
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