ENPEP and CCK

Number of citations of the paper that reports this interaction (PubMedID 8804068)
0

Data Source:
HPRD (in vitro, in vivo)

		ENPEP	CCK
Description		glutamyl aminopeptidase	cholecystokinin
Image
GO Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Brush Border External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Extracellular Exosome	Extracellular Region Extracellular Space Axon
	Molecular Function	Aminopeptidase Activity Glutamyl Aminopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity	Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Angiogenesis Angiotensin Maturation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Cell-cell Signaling Cell Population Proliferation Cell Migration Glomerulus Development Peptide Catabolic Process	Neuron Migration Signal Transduction Axonogenesis Digestion Cholecystokinin Signaling Pathway Eating Behavior
Pathways		Metabolism of Angiotensinogen to Angiotensins	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Glutamic acid	Camostat
Diseases
GWAS		Atrial fibrillation/atrial flutter ( 17603472) Blood pressure ( 21572416) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hypertension ( 30487518) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Iris heterochromicity ( 29109912) Lung cancer ( 28604730) Mean arterial pressure ( 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolic traits ( 21886157) Pursuit maintenance gain ( 29064472) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748) Systolic blood pressure ( 28135244 30487518 30578418)	Adult body size ( 32376654) Body mass index ( 24348519 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body size at age 10 ( 32376654) Night sleep phenotypes ( 27126917)
Interacting Genes		2 interacting genes: AGT CCK	7 interacting genes: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2
Entrez ID		2028	885
HPRD ID		08848	00321
Ensembl ID		ENSG00000138792	ENSG00000187094
Uniprot IDs		Q07075	P06307 Q6FG82
PDB IDs		4KX7 4KX8 4KX9 4KXA 4KXB 4KXC 4KXD	7EZH 7EZK 7EZM 7MBX 7MBY 7XOU 8IA7 9BKJ 9BKK
Enriched GO Terms of Interacting Partners?		Hormone Activity Receptor Ligand Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Membrane Hyperpolarization Response To Muscle Activity Involved In Regulation Of Muscle Adaptation G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Renal Output By Angiotensin Type 2 Angiotensin Receptor Binding Cholecystokinin Signaling Pathway Regulation Of Membrane Hyperpolarization Type 1 Angiotensin Receptor Binding Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Angiotensin-activated Signaling Pathway Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly Regulation Of Renal Sodium Excretion Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Nitric Oxide-cGMP-mediated Signaling Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Gap Junction Assembly Positive Regulation Of Extracellular Matrix Assembly Peptide Hormone Receptor Binding Negative Regulation Of Sodium Ion Transport Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Superoxide Anion Generation Negative Regulation Of MAP Kinase Activity G Protein-coupled Receptor Signaling Pathway Low-density Lipoprotein Particle Remodeling Positive Regulation Of Superoxide Anion Generation Nitric Oxide Mediated Signal Transduction Renal Sodium Ion Absorption Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Extracellular Matrix Assembly Renal Sodium Ion Transport Regulation Of Cardiac Conduction Vasoconstriction Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Extracellular Matrix Organization Sodium Channel Regulator Activity CGMP-mediated Signaling Response To Muscle Activity Regulation Of Superoxide Metabolic Process	Cholecystokinin Receptor Activity Metallopeptidase Activity Meprin A Complex Cholecystokinin Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Regulation Of Hormone Levels Proteolysis Protein Processing Hormone Metabolic Process Plasma Membrane Peptide Hormone Binding Protein Maturation Peptide Metabolic Process Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Glutamyl Aminopeptidase Activity Metalloendopeptidase Activity Neuropeptide Signaling Pathway Epidermal Growth Factor Receptor Ligand Maturation Negative Regulation Of G Protein-coupled Receptor Internalization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Localization To Secretory Granule Regulation Of Biological Quality Membrane Extracellular Space Negative Regulation Of Clathrin-dependent Endocytosis Hydrolase Activity Protein Metabolic Process 1-phosphatidylinositol-3-kinase Regulator Activity G Protein-coupled Receptor Signaling Pathway PH Reduction Gastric Acid Secretion Metallodipeptidase Activity Insulin Processing Cytoplasmic Vesicle Zinc Ion Binding Cardiac Left Ventricle Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Neurexin Family Protein Binding Glomerulus Development Negative Regulation Of Receptor Internalization Insulin Metabolic Process Peptide Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Neuropeptide Receptor Activity G Protein-coupled Receptor Activity
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