ENPEP

Description		glutamyl aminopeptidase
Image
GO Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Brush Border External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Extracellular Exosome
	Molecular Function	Aminopeptidase Activity Glutamyl Aminopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Angiogenesis Angiotensin Maturation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Cell-cell Signaling Cell Population Proliferation Cell Migration Glomerulus Development Peptide Catabolic Process
Pathways		Metabolism of Angiotensinogen to Angiotensins
Drugs		Glutamic acid
Diseases
GWAS		Atrial fibrillation/atrial flutter ( 17603472) Blood pressure ( 21572416) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hypertension ( 30487518) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Iris heterochromicity ( 29109912) Lung cancer ( 28604730) Mean arterial pressure ( 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolic traits ( 21886157) Pursuit maintenance gain ( 29064472) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748) Systolic blood pressure ( 28135244 30487518 30578418)
Interacting Genes		2 interacting genes: AGT CCK
Entrez ID		2028
HPRD ID		08848
Ensembl ID		ENSG00000138792
Uniprot IDs		Q07075
PDB IDs		4KX7 4KX8 4KX9 4KXA 4KXB 4KXC 4KXD
Enriched GO Terms of Interacting Partners?		Hormone Activity Receptor Ligand Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Membrane Hyperpolarization Response To Muscle Activity Involved In Regulation Of Muscle Adaptation G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Renal Output By Angiotensin Type 2 Angiotensin Receptor Binding Cholecystokinin Signaling Pathway Regulation Of Membrane Hyperpolarization Type 1 Angiotensin Receptor Binding Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Angiotensin-activated Signaling Pathway Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly Regulation Of Renal Sodium Excretion Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Nitric Oxide-cGMP-mediated Signaling Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Gap Junction Assembly Positive Regulation Of Extracellular Matrix Assembly Peptide Hormone Receptor Binding Negative Regulation Of Sodium Ion Transport Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Superoxide Anion Generation Negative Regulation Of MAP Kinase Activity G Protein-coupled Receptor Signaling Pathway Low-density Lipoprotein Particle Remodeling Positive Regulation Of Superoxide Anion Generation Nitric Oxide Mediated Signal Transduction Renal Sodium Ion Absorption Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Extracellular Matrix Assembly Renal Sodium Ion Transport Regulation Of Cardiac Conduction Vasoconstriction Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Extracellular Matrix Organization Sodium Channel Regulator Activity CGMP-mediated Signaling Response To Muscle Activity Regulation Of Superoxide Metabolic Process
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