ENPEP

Gene Name		glutamyl aminopeptidase (aminopeptidase A)
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Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border External Side Of Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Aminopeptidase Activity Metallopeptidase Activity Zinc Ion Binding Metalloaminopeptidase Activity
	Biological Process	Angiogenesis Angiotensin Maturation Angiotensin Catabolic Process In Blood Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Cell-cell Signaling Cell Proliferation Cell Migration Glomerulus Development Cellular Protein Metabolic Process
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs
Diseases
GWAS		Atrial fibrillation/atrial flutter ( 17603472) Blood pressure ( 21572416) Metabolic traits ( 21886157)
Protein-protein Interactions		2 interactors: AGT CCK
Entrez ID		2028
HPRD ID		08848
Ensembl ID
Uniprot IDs		Q07075
PDB IDs		4KX7 4KX8 4KX9 4KXA 4KXB 4KXC 4KXD
Enriched GO Terms of Interacting Partners?		Regulation Of Neurological System Process Feeding Behavior Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Ion Homeostasis Regulation Of Peptidyl-tyrosine Phosphorylation Uterine Smooth Muscle Contraction Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Protein Processing Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Catenin Import Into Nucleus Smooth Muscle Cell Proliferation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Angiotensin-mediated Drinking Behavior Regulation Of Renal Output By Angiotensin Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidase Activity Fibroblast Proliferation Astrocyte Activation Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Cellular Ketone Metabolic Process Establishment Of Blood-nerve Barrier Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Activation Of JAK2 Kinase Activity Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Activation Of Janus Kinase Activity Drinking Behavior Artery Smooth Muscle Contraction Positive Regulation Of Apoptotic Process Behavior Positive Regulation Of Programmed Cell Death Tonic Smooth Muscle Contraction Brain Renin-angiotensin System Positive Regulation Of Cell Death Positive Regulation Of Cholesterol Esterification Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Superoxide Anion Generation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Mitochondrial Depolarization Regulation Of Cholesterol Esterification Negative Regulation Of Appetite
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