PRIMPOL and USP36

Number of citations of the paper that reports this interaction (PubMedID 33237263)
51

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		PRIMPOL	USP36
Description		primase and DNA directed polymerase	ubiquitin specific peptidase 36
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Replication Fork Chromosome Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Chromatin Binding DNA-directed DNA Polymerase Activity DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Manganese Ion Binding DNA Polymerase Activity Metal Ion Binding	RNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Transferase Activity Hydrolase Activity Histone H2B Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	DNA-templated DNA Replication Mitochondrial DNA Replication DNA Replication, Synthesis Of Primer DNA Repair DNA Damage Response Response To UV Translesion Synthesis Replication Fork Processing Error-prone Translesion Synthesis Mitochondrial DNA Repair R-loop Processing	Chromatin Organization Chromatin Remodeling Proteolysis Nucleolus Organization Negative Regulation Of Macroautophagy Protein Deubiquitination Regulation Of Protein Stability Regulation Of Apoptotic Process Protein Stabilization Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of RRNA Processing
Pathways
Drugs
Diseases
GWAS			Atrial fibrillation ( 30061737) Diverticular disease ( 30177863) Heel bone mineral density ( 30598549) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418 31928498)
Interacting Genes		6 interacting genes: CDKN2D MPP1 NAV1 PSMA1 RPA1 USP36	19 interacting genes: ALKBH5 EXOSC10 H2BC3 MIR128-1 MIR138-2 MIR15B MIR16-1 MIR17 MIR19B2 MIR21 MIR29A MIR29C MIR34B MIR7-1 MYC PRIMPOL PTBP1 SUMO2 UBE2I
Entrez ID		201973	57602
HPRD ID		08742	07164
Ensembl ID		ENSG00000164306	ENSG00000055483
Uniprot IDs		A0A5S6SZ32 Q96LW4	A0A075B784 Q9P275
PDB IDs		5L2X 5N85 5N8A 7JK1 7JKL 7JKP 7JL8 7JLG	8BS3 8BS9
Enriched GO Terms of Interacting Partners?			MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Translation Positive Regulation Of Connective Tissue Replacement Extracellular Vesicle Regulation Of Connective Tissue Replacement Regulation Of Gene Expression Positive Regulation Of Tissue Remodeling Regulation Of Macromolecule Biosynthetic Process Regulation Of Endothelial Cell Proliferation Negative Regulation Of Amyloid-beta Formation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Developmental Process Regulation Of Amide Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition
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