SMIM14 and LSM4

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		SMIM14	LSM4
Description		small integral membrane protein 14	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol Membrane Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding Protein Binding U6 SnRNA Binding PH Domain Binding
	Biological Process	Blastocyst Hatching	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process RNA Processing MRNA Processing RNA Splicing P-body Assembly
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Triglyceride levels ( 32203549)	Chronotype ( 30696823) Estimated glomerular filtration rate ( 30604766) Gastroesophageal reflux disease ( 31527586) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 32888494)
Interacting Genes		5 interacting genes: FATE1 LSM4 SGTA SLPI TMEM42	21 interacting genes: CALCOCO2 COX5B EXOSC8 GAS7 HOMEZ IKZF1 L3MBTL3 NMI PLEKHA5 PSTPIP1 RHOXF2 SLC22A2 SMIM14 SMN1 SMU1 SNRPE TOE1 TOP1 UBC XRN1 ZBTB10
Entrez ID		201895	25804
HPRD ID		14129	06284
Ensembl ID		ENSG00000163683	ENSG00000130520
Uniprot IDs		Q96QK8	Q9Y4Z0 U3KQK1
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?			Nucleoplasm SMN-Sm Protein Complex RRNA Catabolic Process Nuclear MRNA Surveillance Precatalytic Spliceosome SnRNA 3'-end Processing
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