ZBTB7C and SREBF1

Number of citations: 32 (PubMedID 22331133)
Data Source: BioGRID (two hybrid)

		ZBTB7C	SREBF1
Name		zinc finger and BTB domain containing 7C	sterol regulatory element binding transcription factor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Biosynthetic Process Response To Nutrient Circadian Rhythm Steroid Metabolic Process Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Glucose Response To Fructose Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Insulin Secretion Lung Development Intracellular Receptor Signaling Pathway Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone Cellular Response To Insulin Stimulus SREBP Signaling Pathway Response To Glucagon Response To Lipid MRNA Transcription By RNA Polymerase II Response To Peptide Hormone Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Response To CAMP Response To Fatty Acid Cellular Response To Fatty Acid Negative Regulation Of Triglyceride Metabolic Process Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Regulation Of Protein Targeting To Mitochondrion
Pathways		None	Cholesterol biosynthesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		None	Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
GWAS		Blood urea nitrogen levels ( 31152163 ) Body size at age 10 ( 32376654 ) Ferritin levels ( 33491795 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Lung cancer in ever smokers ( 28604730 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Rheumatoid arthritis ( 30891314 ) Systemic juvenile idiopathic arthritis ( 27927641 ) Weight ( 28552196 )	Coffee consumption ( 31046077 ) Eosinophil count ( 32888494 ) Hip index ( 34021172 ) Lymphocyte count ( 32888494 ) Parkinson's disease ( 21738487 ) Resting heart rate ( 27798624 ) Schizophrenia ( 25056061 28991256 29483656 ) TB-LM or TBLH-BMD (pleiotropy) ( 28743860 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 )
Novel Interactors		None recorded	1 novel interactors: MAPK7
Interacting Genes		3 interacting genes: JUN SREBF1 ZBTB17	42 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP DDX39B EP300 ESR1 ESR2 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MECOM MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 NR5A2 PLK1 PRMT5 SMARCC1 SMARCD3 SP1 SUMO1 TWIST2 UBE2I YY1 ZBTB7C
Entrez ID		201501	6720
HPRD ID		18950	01701
Ensembl ID		ENSG00000184828	ENSG00000072310
Uniprot IDs		A1YPR0 B2RG49	B3KR77 P36956
PDB IDs		Not available	1AM9
GO Terms Enriched among Interactors		Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Anisomycin Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Leading Edge Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Sterol Response Element Binding Response To Anisomycin Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Response To Xenobiotic Stimulus Positive Regulation Of RNA Biosynthetic Process Release From Viral Latency Positive Regulation Of DNA-templated Transcription Regulation Of Heart Rate By Chemical Signal Transcription Factor AP-1 Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Host-mediated Suppression Of Viral Transcription Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Eyelid Development In Camera-type Eye Negative Regulation Of Biosynthetic Process DNA Binding CAMP Response Element Binding General Transcription Initiation Factor Binding Response To Sterol Depletion Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Metabolic Process Response To Fructose Ectoderm Development G1 To G0 Transition Negative Regulation Of DNA Binding Sequence-specific Double-stranded DNA Binding Host-mediated Suppression Of Viral Proces Negative Regulation Of Macromolecule Metabolic Process Monocyte Differentiation Regulation Of Transcription By RNA Polymerase II Host-mediated Activation Of Viral Transcription	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mediator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Core Mediator Complex Positive Regulation Of Transcription Initiation By RNA Polymerase II Nucleus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Initiation Transcription Coregulator Activity Transcription Preinitiation Complex Assembly Transcription Coactivator Activity Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Vitamin D Receptor Binding Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Somatic Stem Cell Population Maintenance Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Rhythmic Process