ELAVL2 and IL11RA

		ELAVL2	IL11RA
Description		ELAV like RNA binding protein 2	interleukin 11 receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Ribonucleoprotein Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-11 Receptor Activity Protein Binding Interleukin-11 Binding
	Biological Process	Regulation Of DNA-templated Transcription	Embryo Implantation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cell Differentiation Developmental Process Interleukin-11-mediated Signaling Pathway Head Development
Pathways			IL-6-type cytokine receptor ligand interactions
Drugs			Oprelvekin
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 34103634 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Attending social / leisure activities ( 34054130) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Chronic obstructive pulmonary disease ( 30804561) Feeling guilty ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fulminant type 1 diabetes ( 30552108) General cognitive ability ( 29844566) Glomerular filtration rate change in heart transplantation ( 30160337) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intelligence (MTAG) ( 29326435) Lung function (FEV1/FVC) ( 30061609) Neurociticism ( 29500382) Neuroticism ( 27067015 29255261 27089181) Physiological traits ( 31902109) Plasma t-tau levels ( 28100725) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Schizophrenia ( 33169155) Sociability score ( 34054130)	CTACK levels ( 27989323)
Interacting Genes		6 interacting genes: ELAVL3 ELAVL4 HNRNPAB HOXC9 NR2E3 RBFOX2	3 interacting genes: IL11 OLFM4 USP40
Entrez ID		1993	3590
HPRD ID		03396	02965
Ensembl ID		ENSG00000107105	ENSG00000137070
Uniprot IDs		A0A0A0MRX1 Q12926	Q14626
PDB IDs			6O4P 8DPS 8DPT 8DPU 8QY4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MRNA Catabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Ribonucleoprotein Complex MRNA 3'-UTR Binding Developmental Process MRNA 3'-UTR AU-rich Region Binding Nucleic Acid Binding Cellular Developmental Process MRNA Binding Negative Regulation Of RNA Metabolic Process RNA Metabolic Process MRNA Stabilization Cell Differentiation RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Stabilization Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Pre-mRNA Intronic Pyrimidine-rich Binding Negative Regulation Of Catabolic Process Nuclear Receptor-mediated Signaling Pathway Cellular Response To Cell-matrix Adhesion MRNA Editing Complex Interleukin-11 Receptor Activity Interleukin-11 Binding Selenocysteine Insertion Sequence Binding Chromosomal 5-methylcytosine DNA Demethylation Pathway Hormone-mediated Signaling Pathway Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Nucleic Acid Metabolic Process Regulation Of Intracellular MRNA Localization Neuronal Ribonucleoprotein Granule Positive Regulation Of Gene Expression Interleukin-11-mediated Signaling Pathway MRNA Metabolic Process Neuron Development Selenocysteine Incorporation Regulation Of MRNA Stability Regulation Of RNA Metabolic Process Regulation Of RNA Stability Megakaryocyte Differentiation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Intracellular Receptor Signaling Pathway	Interleukin-11 Receptor Binding Dendritic Cell Dendrite Assembly Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Dendritic Cell Dendrite Assembly Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Chemokine (C-C Motif) Ligand 21 Signaling Pathway Cytokine Activity Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Cell-substrate Adhesion Interleukin-11-mediated Signaling Pathway Megakaryocyte Differentiation Regulation Of Complement-dependent Cytotoxicity Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Immunological Synapse Formation Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of Canonical NF-kappaB Signal Transduction Chemokine Receptor Binding Establishment Of T Cell Polarity Negative Regulation Of Cellular Extravasation Azurophil Granule Specific Granule Regulation Of Leukocyte Tethering Or Rolling Regulation Of T Cell Chemotaxis Cellular Response To Chemokine Dendritic Cell Chemotaxis Cytokine-mediated Signaling Pathway Extracellular Space Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Glycoprotein Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Lymphocyte Chemotaxis
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