DNAH10 and GATC

		DNAH10	GATC
Description		dynein axonemal heavy chain 10	glutamyl-tRNA amidotransferase subunit C
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Dynein Complex Cell Projection 9+2 Motile Cilium	Mitochondrion Glutamyl-tRNA(Gln) Amidotransferase Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Nucleotide Binding Protein Binding ATP Binding Ligase Activity Carbon-nitrogen Ligase Activity, With Glutamine As Amido-N-donor Glutaminyl-tRNA Synthase (glutamine-hydrolyzing) Activity
	Biological Process	Microtubule-based Process Microtubule-based Movement Cilium Movement Involved In Cell Motility	Translation Regulation Of Translational Fidelity Mitochondrial Translation Glutaminyl-tRNAGln Biosynthesis Via Transamidation
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 22479202 31178129) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015) Coronary artery disease ( 29212778) Fasting insulin ( 34059833) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172 28552196) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494 27863252) Osteoarthritis (hip) ( 23989986) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 30389748 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500) White blood cell count ( 32888494)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 32888494)
Interacting Genes		1 interacting genes: LINC00839	6 interacting genes: ALOX5 CTAG1A CTAG1B HGS SRSF11 TOMM20L
Entrez ID		196385	283459
HPRD ID		13473	15934
Ensembl ID		ENSG00000197653	ENSG00000257218
Uniprot IDs		A0A669KB38 B0I1S1 Q8IVF4	O43716
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?		Protein Transport From Ciliary Membrane To Plasma Membrane Glutaminyl-tRNAGln Biosynthesis Via Transamidation Glutaminyl-tRNA Synthase (glutamine-hydrolyzing) Activity Carbon-nitrogen Ligase Activity, With Glutamine As Amido-N-donor Glutamyl-tRNA(Gln) Amidotransferase Complex	TRNA Threonylcarbamoyladenosine Metabolic Process Leukotriene A4 Metabolic Process Arachidonate Metabolite Production Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Negative Regulation Of Vasculature Development Arachidonate 8(S)-lipoxygenase Activity Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Negative Regulation Of Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen ESCRT-0 Complex Phagocytic Vesicle Lumen TRNA Import Into Mitochondrion Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process RNA Import Into Mitochondrion Mitochondrion Targeting Sequence Binding TRNA Transport TRNA Metabolic Process Negative Regulation Of Vascular Wound Healing Protein Targeting Leukocyte Chemotaxis Involved In Inflammatory Response Mitochondrial Outer Membrane Translocase Complex Lipoxygenase Pathway
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