EIF2D and HEXB

Number of citations of the paper that reports this interaction (PubMedID 7299841)
0

Data Source:
HPRD (in vitro)

		EIF2D	HEXB
Description		eukaryotic translation initiation factor 2D	hexosaminidase subunit beta
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GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Body	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Membrane Cytoplasmic Vesicle Azurophil Granule Lumen Azurophil Granule Lysosomal Lumen Cortical Granule Extracellular Exosome Beta-N-acetylhexosaminidase Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Signaling Receptor Activity	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Hexosaminidase Activity Beta-N-acetylglucosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Intracellular Protein Transport Ribosome Disassembly Protein-containing Complex Organization IRES-dependent Viral Translational Initiation	Skeletal System Development Carbohydrate Metabolic Process N-acetylglucosamine Metabolic Process N-glycan Processing Lipid Metabolic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Intracellular Calcium Ion Homeostasis Lysosome Organization Single Fertilization Penetration Of Zona Pellucida Sensory Perception Of Sound Locomotory Behavior Male Courtship Behavior Regulation Of Cell Shape Phospholipid Biosynthetic Process Oligosaccharide Catabolic Process Regulation Of Metabolic Process Lipid Storage Sexual Reproduction Glycosaminoglycan Metabolic Process Chondroitin Sulfate Proteoglycan Catabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Hyaluronan Catabolic Process Myelination Astrocyte Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Cellular Homeostasis Carbohydrate Derivative Metabolic Process
Pathways			Keratan sulfate degradation CS/DS degradation Hyaluronan degradation Defective HEXB causes GM2G2 (Hyaluronan metabolism) Neutrophil degranulation Glycosphingolipid catabolism
Drugs			Pyrimethamine 2-Acetamido-2-Deoxy-D-Glucono-1,5-Lactone N-Acetyl-glucosamine thiazoline (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidine
Diseases			GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Ceramide levels (C24:0) ( 32489964)	Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		2 interacting genes: ACHE HEXB	6 interacting genes: AIRE CSNK2B EIF2D FAM210B HOXA1 TMEM14B
Entrez ID		1939	3074
HPRD ID		01057	06043
Ensembl ID		ENSG00000143486	ENSG00000049860
Uniprot IDs		P41214	A0A024RAJ6 P07686 Q5URX0
PDB IDs		5OA3 5OA9 5W2F	1NOU 1NOW 1NP0 1O7A 2GJX 2GK1 3LMY 5BRO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Transmission, Cholinergic Cell Development Side Of Membrane Beta-N-acetylglucosaminidase Activity Male Courtship Behavior Plasma Membrane Raft Distribution Acetylcholinesterase Activity Acetylcholine Catabolic Process In Synaptic Cleft Beta-N-acetylhexosaminidase Complex Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Acetylcholine Catabolic Process Cholinesterase Activity Chondroitin Sulfate Proteoglycan Catabolic Process Hexosaminidase Activity Membrane Microdomain Beta-N-acetylhexosaminidase Activity Dermatan Sulfate Proteoglycan Catabolic Process DN2 Thymocyte Differentiation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Hydrolase Activity Cortical Granule Serine Hydrolase Activity Astrocyte Cell Migration Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Male Mating Behavior Membrane Raft Distribution Bone Marrow Development Ganglioside Catabolic Process Negative Regulation Of Microglial Cell Activation Protein Tyrosine Kinase Inhibitor Activity Membrane Raft Localization Acetylcholine Binding Positive Regulation Of Gamma-delta T Cell Differentiation Bleb Azurophil Granule Penetration Of Zona Pellucida Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Positive Thymic T Cell Selection Negative Thymic T Cell Selection Dermatan Sulfate Proteoglycan Metabolic Process Hyaluronan Catabolic Process Negative T Cell Selection Sexual Reproduction	Regulation Of Thymocyte Migration Central Tolerance Induction To Self Antigen Central Tolerance Induction Tolerance Induction Dependent Upon Immune Response Thymus Epithelium Morphogenesis Peripheral T Cell Tolerance Induction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Viral Process Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Identical Protein Binding Tolerance Induction To Self Antigen Release From Viral Latency T Cell Tolerance Induction Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Adiponectin-activated Signaling Pathway Formation Of Translation Preinitiation Complex Embryonic Neurocranium Morphogenesis Outer Ear Morphogenesis Negative Thymic T Cell Selection Negative T Cell Selection Female Germ Cell Nucleus Tube Morphogenesis Endothelial Tube Morphogenesis IRES-dependent Viral Translational Initiation
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