EIF2D

Description		eukaryotic translation initiation factor 2D
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GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Body
	Molecular Function	RNA Binding Translation Initiation Factor Activity Signaling Receptor Activity
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Intracellular Protein Transport Ribosome Disassembly Protein-containing Complex Organization IRES-dependent Viral Translational Initiation
Pathways
Drugs
Diseases
GWAS		Ceramide levels (C24:0) ( 32489964)
Novel Interacting Genes		1 novel interacting genes: PTPRC
Interacting Genes		2 interacting genes: ACHE HEXB
Entrez ID		1939
HPRD ID		01057
Ensembl ID		ENSG00000143486
Uniprot IDs		P41214
PDB IDs		5OA3 5OA9 5W2F
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Transmission, Cholinergic Cell Development Side Of Membrane Beta-N-acetylglucosaminidase Activity Male Courtship Behavior Plasma Membrane Raft Distribution Acetylcholinesterase Activity Acetylcholine Catabolic Process In Synaptic Cleft Beta-N-acetylhexosaminidase Complex Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Acetylcholine Catabolic Process Cholinesterase Activity Chondroitin Sulfate Proteoglycan Catabolic Process Hexosaminidase Activity Membrane Microdomain Beta-N-acetylhexosaminidase Activity Dermatan Sulfate Proteoglycan Catabolic Process DN2 Thymocyte Differentiation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Hydrolase Activity Cortical Granule Serine Hydrolase Activity Astrocyte Cell Migration Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Male Mating Behavior Membrane Raft Distribution Bone Marrow Development Ganglioside Catabolic Process Negative Regulation Of Microglial Cell Activation Protein Tyrosine Kinase Inhibitor Activity Membrane Raft Localization Acetylcholine Binding Positive Regulation Of Gamma-delta T Cell Differentiation Bleb Azurophil Granule Penetration Of Zona Pellucida Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Positive Thymic T Cell Selection Negative Thymic T Cell Selection Dermatan Sulfate Proteoglycan Metabolic Process Hyaluronan Catabolic Process Negative T Cell Selection Sexual Reproduction
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