DYNC1H1 and ATP2B3

		DYNC1H1	ATP2B3
Description		dynein cytoplasmic 1 heavy chain 1	ATPase plasma membrane Ca2+ transporting 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Filopodium Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm	Plasma Membrane Membrane Presynaptic Membrane Cell Projection Intracellular Membrane-bounded Organelle Synapse Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse GABA-ergic Synapse Extracellular Vesicle Parallel Fiber
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Identical Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Nucleotide Binding P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Metal Ion Binding P-type Calcium Transporter Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly	Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs			Ritodrine Halothane Desflurane Sevoflurane
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		25 interacting genes: BRCA1 BTG3 CEBPA COX20 DISC1 DSCAM DSCR9 DUX4 DYNLL1 EGFR FILNC1 ITSN1 KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ	1 interacting genes: HTR2C
Entrez ID		1778	492
HPRD ID		02524	02057
Ensembl ID		ENSG00000197102	ENSG00000067842
Uniprot IDs		Q14204	A0A994J5M1 Q16720
PDB IDs		5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A 7Z8F 7Z8G 7Z8H 7Z8I 7Z8J 7Z8K 7Z8L 8DYU 8DYV 8FCY 8FD6 8FDT 8FDU 8PQV 8PQW 8PQY 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing BRCA1-C Complex Cerebral Cortex Cell Migration Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Telencephalon Cell Migration Signal Transduction Forebrain Cell Migration Microtubule Severing	Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding G Protein-coupled Serotonin Receptor Complex Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Spindle Assembly Regulation Of Metaphase Plate Congression P-body Assembly Minus-end-directed Microtubule Motor Activity G Protein-coupled Serotonin Receptor Activity Serotonin Binding Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Activity Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Signaling Pathway Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity Retrograde Axonal Transport G Protein-coupled Serotonin Receptor Signaling Pathway Cytoplasmic Dynein Complex Regulation Of Appetite Nucleus Localization Stress Granule Assembly Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Dynein Complex Regulation Of Spindle Assembly Nuclear Migration Behavioral Fear Response Regulation Of Phospholipid Metabolic Process Behavioral Defense Response CGMP-mediated Signaling Fear Response Regulation Of Mitotic Spindle Organization Establishment Of Spindle Localization Cytoplasmic Microtubule Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Sequestering Of Calcium Ion Axon Cytoplasm Axonal Transport Spindle Localization Cytoplasmic Microtubule Organization Positive Regulation Of Fat Cell Differentiation Multicellular Organismal Response To Stress Regulation Of Transport Filopodium Axo-dendritic Transport Feeding Behavior
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