DYNC1H1 and ASB7

		DYNC1H1	ASB7
Description		dynein cytoplasmic 1 heavy chain 1	ankyrin repeat and SOCS box containing 7
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Filopodium Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm	Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Identical Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding
	Biological Process	Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly	Protein Ubiquitination Intracellular Signal Transduction
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)	Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Chin dimples ( 27182965) Chronotype ( 30696823) Lower body strength ( 27325353) Morning person ( 30696823) Optic cup area ( 25631615 28073927 31798171) Optic disc area ( 28073927) Response to taxane treatment (paclitaxel) ( 23006423) Vertical cup-disc ratio ( 28073927 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		25 interacting genes: BRCA1 BTG3 CEBPA COX20 DISC1 DSCAM DSCR9 DUX4 DYNLL1 EGFR FILNC1 ITSN1 KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ	3 interacting genes: ATF4 CDK2 PSRC1
Entrez ID		1778	140460
HPRD ID		02524	10674
Ensembl ID		ENSG00000197102	ENSG00000183475
Uniprot IDs		Q14204	Q9H672
PDB IDs		5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A 7Z8F 7Z8G 7Z8H 7Z8I 7Z8J 7Z8K 7Z8L 8DYU 8DYV 8FCY 8FD6 8FDT 8FDU 8PQV 8PQW 8PQY 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK	8Y1U
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing BRCA1-C Complex Cerebral Cortex Cell Migration Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Telencephalon Cell Migration Signal Transduction Forebrain Cell Migration Microtubule Severing	Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Cell Division Positive Regulation Of Organelle Organization Regulation Of Mitotic Spindle Organization Organelle Organization Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process Regulation Of Cold-induced Thermogenesis Centrosome CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Chromatin Organization Regulation Of Cell Cycle Process Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization ATF4-CREB1 Transcription Factor Complex Asparagine Metabolic Process X Chromosome Regulation Of Cell Cycle Transcription Regulator Complex GDF15-GFRAL Signaling Pathway Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Regulation Of Microtubule-based Process Positive Regulation Of Metabolic Process Lens Fiber Cell Morphogenesis Protection From Non-homologous End Joining At Telomere Membraneless Organelle Assembly HRI-mediated Signaling Positive Regulation Of Spindle Assembly Regulation Of Phosphate Transport Cellular Response To Manganese Ion Regulation Of Heterochromatin Formation Mitochondrial Respirasome Assembly
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