DNAH9 and STX8

		DNAH9	STX8
Description		dynein axonemal heavy chain 9	syntaxin 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Microtubule Cilium Axoneme Dynein Complex Motile Cilium Outer Dynein Arm Cell Projection Glial Cell Projection 9+2 Motile Cilium Distal Portion Of Axoneme	Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Plasma Membrane Endomembrane System Membrane SNARE Complex Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Cilium Movement Microtubule-based Movement Cell Projection Organization Establishment Of Localization In Cell Cilium Movement Involved In Cell Motility Cerebrospinal Fluid Circulation Mucociliary Clearance	Intracellular Protein Transport Vesicle Fusion Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Type II Interferon Regulation Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Cerebellum growth ( 29682794) Femur bone mineral density x serum urate levels interaction ( 34046847) Immune response to measles-mumps-rubella vaccine ( 24811271) Impulsivity ( 30718321) Myopia (pathological) ( 23049088) Refractive error ( 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)	Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Brain morphology (MOSTest) ( 32665545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
Interacting Genes		1 interacting genes: SRPK2	84 interacting genes: ACVR1 AMIGO1 AQP2 AQP6 ARL13B ASGR2 BCL2L13 BIK BSND CALM1 CD300E CD79A CERS4 CLDN9 CLN8 COPA CPLX4 CREB3 CREB3L1 DHRS9 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GORAB GPR151 GPR152 GPR42 GPX8 JAGN1 JSRP1 KCNMB1 LMNA MCEE MCL1 MFF MGST2 MGST3 MMGT1 MS4A3 MTERF3 NAPA NAPG NCR3LG1 NDUFAF1 NDUFAF2 NSF PEX12 PSCA RETREG3 RNASEK SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC22A2 SLC35H1 SSMEM1 STAR STMN4 STX1A STX2 STX7 TGFBR1 TMED8 TMEM14B TMEM179B TMEM205 TMEM237 TMEM86B TMPPE TMPRSS2 TSPAN12 VPS11 VPS18 VTI1B WDR91
Entrez ID		1770	9482
HPRD ID		04511	05012
Ensembl ID		ENSG00000007174	ENSG00000170310
Uniprot IDs		Q99499 Q9NYC9	Q9UNK0
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T-SNARE Clustering Jump Response Nuclear Speck Organization Regulation Of Protein Localization To Membrane Chloride Channel Inhibitor Activity Translational Attenuation Glycinergic Synapse Ribbon Synapse Postsynaptic Membrane Assembly Terminal Button Organization Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Inhibitory Postsynaptic Potential Symmetric, GABA-ergic, Inhibitory Synapse Positive Regulation Of Protein Localization To Synapse Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Synaptic Vesicle Clustering Thigmotaxis R-loop Processing Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization Neurexin Family Protein Binding Regulation Of Respiratory Gaseous Exchange By Nervous System Process Dopaminergic Synapse Neurotransmitter-gated Ion Channel Clustering Presynapse Assembly Postsynaptic Specialization Assembly Locomotory Exploration Behavior Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Inhibitory Synapse Positive Regulation Of Synaptic Transmission, GABAergic Oocyte Development Nuclear Body Organization Insulin Metabolic Process Presynapse Organization Cell-cell Junction Maintenance Regulation Of Cellular Localization Regulation Of Respiratory Gaseous Exchange Inhibitory Synapse Assembly Early Endosome To Late Endosome Transport Postsynaptic Specialization Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Regulation Of Protein Localization To Synapse Positive Regulation Of Viral Genome Replication Excitatory Synapse	Membrane Syntaxin Binding Endoplasmic Reticulum Membrane SNARE Binding Membrane Fusion SNARE Complex Organelle Localization By Membrane Tethering Membrane Docking Protein Binding Vesicle Docking Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Protein Transport Organelle Fusion Chloride Channel Inhibitor Activity Vesicle Fusion Vesicle-mediated Transport Organelle Membrane Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Endomembrane System SNARE Complex Disassembly Soluble NSF Attachment Protein Activity Membrane Organization Transmembrane Transport Cellular Localization Endoplasmic Reticulum Neurotransmitter Transport Neurotransmitter Reuptake Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutathione Peroxidase Activity Establishment Of Protein Localization Intracellular Transport Transforming Growth Factor Beta Receptor Activity, Type I Leukotriene-C4 Synthase Activity Protein Transport Presynaptic Active Zone Membrane Norepinephrine Uptake Neurotransmitter Uptake Plasma Membrane Golgi Vesicle Transport Activin Receptor Complex Activin Receptor Activity, Type I CORVET Complex Lysosomal Membrane Renal Water Transport Voltage-gated Potassium Channel Complex Serotonin Uptake Norepinephrine Transport Protein-containing Complex Disassembly
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