COCH and NIN

		COCH	NIN
Description		cochlin	ninein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Pericentriolar Material Spindle Pole Nucleoplasm Nucleolus Cytoplasm Centrosome Centriole Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Axon Dendrite Ciliary Basal Body Axonal Growth Cone Apical Part Of Cell Mitotic Spindle Mitotic Spindle Pole Ciliary Transition Fiber Centriolar Subdistal Appendage
	Molecular Function	Protein Binding Collagen Binding	Nucleotide Binding Calcium Ion Binding Protein Binding GTP Binding Microtubule Minus-end Binding
	Biological Process	Sensory Perception Of Sound Regulation Of Cell Shape	Intracellular Protein Localization Centriole-centriole Cohesion Corpus Callosum Morphogenesis Corticospinal Tract Morphogenesis Microtubule Anchoring At Centrosome Collateral Sprouting Positive Regulation Of Axonogenesis Centrosome Localization Centrosome-templated Microtubule Nucleation
Pathways
Drugs
Diseases		Deafness, autosomal dominant
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 27863252) Night sleep phenotypes ( 27126917)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Cognitive performance ( 20125193) Diastolic blood pressure ( 30578418) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 27863252) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Rectal cancer ( 33632709) Refractive error ( 32231278) Schizophrenia ( 33169155) Stroke ( 32693751) Systolic blood pressure ( 30578418)
Interacting Genes		1 interacting genes: CLK1	17 interacting genes: ABI1 AUNIP AURKA BICD1 GSK3B GTSE1 KLC1 PIAS1 PRKACA PRPF6 RBM10 RTRAF SNW1 SUMO1 UBE2I UTP14A YWHAE
Entrez ID		1690	51199
HPRD ID		04431	09785
Ensembl ID		ENSG00000100473	ENSG00000100503
Uniprot IDs		A0A2U3TZE7 O43405	C9J066 E9PN67 Q5XUU0 Q8N4C6
PDB IDs		1JBI
Enriched GO Terms of Interacting Partners?		Microtubule Anchoring At Centrosome Corticospinal Tract Morphogenesis Centriolar Subdistal Appendage Ciliary Transition Fiber Centriole-centriole Cohesion Microtubule Nucleation By Microtubule Organizing Center Microtubule Minus-end Binding Corpus Callosum Morphogenesis Centrosome-templated Microtubule Nucleation Microtubule Anchoring At Microtubule Organizing Center Collateral Sprouting Protein Serine/threonine/tyrosine Kinase Activity Axonal Growth Cone Pericentriolar Material Central Nervous System Projection Neuron Axonogenesis Microtubule Nucleation Microtubule Anchoring Central Nervous System Neuron Axonogenesis Centrosome Localization Mitotic Spindle Pole Non-membrane Spanning Protein Tyrosine Kinase Activity Cytoplasmic Microtubule Positive Regulation Of Axonogenesis Nucleotide Binding Apical Part Of Cell	Regulation Of Nucleocytoplasmic Transport Nuclear Speck Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Export From Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Small Protein Activating Enzyme Binding PML Body Centrosome Peptidyl-serine Phosphorylation Regulation Of Intracellular Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome Regulation Of Intracellular Protein Transport Cellular Response To Heat Protein Sumoylation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Processing Regulation Of Protein Localization To Centrosome RNA Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Localization To Organelle Dynactin Binding Positive Regulation Of Protein Catabolic Process Enzyme Binding Response To Heat Positive Regulation Of Intracellular Protein Transport Intracellular Potassium Ion Homeostasis Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Transcription Factor Binding SUMO Transferase Activity Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Metabolic Process Regulation Of Cellular Localization Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Protein Metabolic Process Nuclear Export Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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