DCP2 and TMED7

		DCP2	TMED7
Description		decapping mRNA 2	transmembrane p24 trafficking protein 7
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Membrane COPI Vesicle Coat COPII Vesicle Coat Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	RNA Binding 5'-3' RNA Exonuclease Activity Protein Binding Hydrolase Activity RNA Exonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding Metal Ion Binding Telomerase RNA Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Histone MRNA Catabolic Process Regulation Of Telomerase RNA Localization To Cajal Body	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Waist circumference ( 32902719) Worry/vulnerability (special factor of neuroticism) ( 30867560)	Hip circumference adjusted for BMI ( 34021172) Liver injury in combined anti-retroviral and anti-tuberculosis drug-treated HIV with tuberculosis ( 28388302) Response to antidepressants (symptom improvement) ( 29160301) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2	1 interacting genes: TMPRSS3
Entrez ID		167227	51014
HPRD ID		13125	13029
Ensembl ID		ENSG00000172795	ENSG00000134970
Uniprot IDs		Q8IU60	Q9Y3B3
PDB IDs		5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC
Enriched GO Terms of Interacting Partners?		P-body Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process RNA Catabolic Process Cytoplasmic Ribonucleoprotein Granule SiRNA-mediated Gene Silencing By MRNA Destabilization Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Gene Expression Positive Regulation Of Catabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation RISC-loading Complex Negative Regulation Of Protein Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Translation RISC Complex Assembly 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Cytosol Regulation Of Translation RNA Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Pre-miRNA Processing RISC Complex Autophagosome Assembly Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping MRNA Destabilization Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Autophagosome Organization Negative Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Non-canonical NF-kappaB Signal Transduction RNA Decapping Exon-exon Junction Complex MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process MiRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Metabolic Process Telomeric DNA Binding Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process RNA Polymerase II Complex Binding Positive Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process MiRNA Processing	RNA Exonuclease Activity, Producing 5'-phosphomonoesters Intracellular Sodium Ion Homeostasis Telomerase RNA Binding MRNA Methylguanosine-cap Decapping Histone MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity 5'-3' RNA Exonuclease Activity Regulation Of Telomerase RNA Localization To Cajal Body RNA Decapping Histone MRNA Metabolic Process Sodium Ion Homeostasis Sodium Channel Regulator Activity Negative Regulation Of Telomere Maintenance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Manganese Ion Binding Hydrolase Activity Negative Regulation Of Chromosome Organization Cytoplasmic Ribonucleoprotein Granule Regulation Of DNA Biosynthetic Process RISC Complex MRNA Destabilization P-body RNA Destabilization Nuclear-transcribed MRNA Catabolic Process Regulation Of Telomere Maintenance Positive Regulation Of MRNA Catabolic Process
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