DCP2 and CYP27A1

		DCP2	CYP27A1
Description		decapping mRNA 2	cytochrome P450 family 27 subfamily A member 1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane
	Molecular Function	RNA Binding 5'-3' RNA Exonuclease Activity Protein Binding Hydrolase Activity RNA Exonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding Metal Ion Binding Telomerase RNA Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Vitamin D3 25-hydroxylase Activity Cholesterol 26-hydroxylase Activity Metal Ion Binding Cholestanetetraol 26-dehydrogenase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Histone MRNA Catabolic Process Regulation Of Telomerase RNA Localization To Cajal Body	Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process Cholesterol Catabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Sterol Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Small Molecule Biosynthetic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Endogenous sterols Defective CYP27A1 causes CTX
Drugs
Diseases			Cerebrotendinous xanthomatosis; Van Bogaert-Scherer-Epstein Disease
GWAS		Waist circumference ( 32902719) Worry/vulnerability (special factor of neuroticism) ( 30867560)	Diastolic blood pressure ( 30224653) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) Male-pattern baldness ( 28196072) Reticulocyte count ( 27863252)
Interacting Genes		12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2	2 interacting genes: MTDH PRDX4
Entrez ID		167227	1593
HPRD ID		13125	05939
Ensembl ID		ENSG00000172795	ENSG00000135929
Uniprot IDs		Q8IU60	Q02318
PDB IDs		5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC
Enriched GO Terms of Interacting Partners?		P-body Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process RNA Catabolic Process Cytoplasmic Ribonucleoprotein Granule SiRNA-mediated Gene Silencing By MRNA Destabilization Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Gene Expression Positive Regulation Of Catabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation RISC-loading Complex Negative Regulation Of Protein Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Translation RISC Complex Assembly 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Cytosol Regulation Of Translation RNA Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Pre-miRNA Processing RISC Complex Autophagosome Assembly Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping MRNA Destabilization Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Autophagosome Organization Negative Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Non-canonical NF-kappaB Signal Transduction RNA Decapping Exon-exon Junction Complex MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process MiRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Metabolic Process Telomeric DNA Binding Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process RNA Polymerase II Complex Binding Positive Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process MiRNA Processing	Regulation Of Germ Cell Proliferation I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Thioredoxin Peroxidase Activity Regulation Of Male Germ Cell Proliferation Intercellular Canaliculus RNA Exonuclease Activity, Producing 5'-phosphomonoesters 5'-3' RNA Exonuclease Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Regulation Of Telomerase RNA Localization To Cajal Body Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Molecular Sequestering Activity Positive Regulation Of Catabolic Process MRNA Methylguanosine-cap Decapping Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Hydrogen Peroxide Catabolic Process RNA Decapping Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Antioxidant Activity Histone MRNA Metabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process NF-kappaB Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Telomere Maintenance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cell Redox Homeostasis Regulation Of Telomere Maintenance Via Telomerase
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