ADGRA3 and HRH1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ADGRA3	HRH1
Description		adhesion G protein-coupled receptor A3	histamine receptor H1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Cytosol Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding	G Protein-coupled Receptor Activity Histamine Receptor Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Memory Visual Learning Regulation Of Vascular Permeability Positive Regulation Of Vasoconstriction Regulation Of Synaptic Plasticity Cellular Response To Histamine
Pathways			Histamine receptors G alpha (q) signalling events
Drugs			Citalopram Benzatropine Ziprasidone Clemastine Amitriptyline Olanzapine Cetirizine Terfenadine Buclizine Clozapine Doxylamine Mirtazapine Dexbrompheniramine Loxapine Promazine Triprolidine Prochlorperazine Cyproheptadine Loratadine Imipramine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Hydroxyzine Cinnarizine Astemizole Trazodone Paroxetine Azatadine Trimipramine Risperidone Meclizine Carbinoxamine Epinastine Benzquinamide Olopatadine Propiomazine Tripelennamine Tolazoline Brompheniramine Methdilazine Repaglinide Ketotifen Maprotiline Fexofenadine Desloratadine Azelastine Dimenhydrinate Promethazine Mequitazine Diphenhydramine Emedastine Levocabastine Chlorpheniramine Doxepin Diphenylpyraline Desipramine Orphenadrine Escitalopram Cyclizine Quetiapine Bromodiphenhydramine Aripiprazole Chlorprothixene Alimemazine Paliperidone Methotrimeprazine Aceprometazine Phenindamine Pheniramine Zuclopenthixol Clofedanol Flunarizine Bepotastine Tesmilifene Iloperidone HY10275 OBE101 SO-101 Histamine Epicept NP-1 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Levocetirizine Esmirtazapine Mepyramine Betahistine Alcaftadine Antazoline Chloropyramine Dimetindene Isothipendyl Perospirone Chlorcyclizine Butriptyline Dosulepin Viloxazine Lorpiprazole Acrivastine Dexchlorpheniramine maleate Thonzylamine Bilastine Rupatadine Aripiprazole lauroxil
Diseases
GWAS			Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Mortality in sepsis ( 27639821) Pulse pressure ( 27841878) Systolic blood pressure ( 27618447 27618452 27841878)
Interacting Genes		3 interacting genes: ADRA1A DLG1 HRH1	12 interacting genes: ACE2 ADGRA3 ATP6V0A1 CD81 CNBP DHRS7 LIMS2 MAT2B SLC35B1 SLC43A2 WLS YIPF3
Entrez ID		166647	3269
HPRD ID		11011	02544
Ensembl ID		ENSG00000152990	ENSG00000196639
Uniprot IDs		Q8IWK6	P35367
PDB IDs			3RZE 7DFL 8YN2
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction Smooth Muscle Contraction Cell-cell Signaling Regulation Of Vasoconstriction Regulation Of System Process Regulation Of Action Potential Signaling Cell Communication Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Muscle Contraction Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Contraction Muscle Contraction Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Structural Constituent Of Postsynaptic Density L27 Domain Binding Regulation Of Muscle System Process System Process Muscle System Process Vascular Process In Circulatory System Lateral Loop Regulation Of ERK1 And ERK2 Cascade Neuron-glial Cell Signaling MPP7-DLG1-LIN7 Complex Maintenance Of Postsynaptic Density Structure Myelin Sheath Abaxonal Region Regulation Of The Force Of Heart Contraction By Chemical Signal Circulatory System Process Chemical Synaptic Transmission Regulation Of Potassium Ion Import Cellular Response To Histamine Histamine Receptor Activity Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Cardiac Muscle Contraction G Protein-coupled Receptor Activity Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity	Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Virus Receptor Activity Myoblast Fusion Involved In Skeletal Muscle Regeneration G-quadruplex DNA Formation UDP-galactose Transmembrane Transport UDP-galactose Transmembrane Transporter Activity UDP-glucose Transmembrane Transporter Activity UDP-glucose Transmembrane Transport Methionine Adenosyltransferase Regulator Activity Methionine Adenosyltransferase Complex Cholangiocyte Proliferation Negative Regulation Of Hepatocyte Proliferation Regulation Of Cholangiocyte Proliferation Negative Regulation Of Cholangiocyte Proliferation Endocytic Vesicle Membrane Organic Cation Transport Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Regulation Of Amine Transport Entry Receptor-mediated Virion Attachment To Host Cell Peptidyl-dipeptidase Activity Wnt Protein Secretion L-methionine Transmembrane Transporter Activity L-isoleucine Transmembrane Transporter Activity L-phenylalanine Transmembrane Transporter Activity Methionine Transport Negative Regulation Of L-leucine Import Across Plasma Membrane Organic Anion Transport Plasma Membrane Negative Regulation Of Transcription By RNA Polymerase III S-adenosylmethionine Biosynthetic Process Viral Translation Viral Life Cycle Positive Regulation Of Wnt Protein Secretion Phenylalanine Transport
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