DENND1B and GLRX2

		DENND1B	GLRX2
Description		DENN domain containing 1B	glutaredoxin 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Speck Clathrin-coated Vesicle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Phosphatidylinositol Phosphate Binding	Protein Disulfide Isomerase Activity Protein Binding Arsenate Reductase (glutaredoxin) Activity Electron Transfer Activity Protein-disulfide Reductase Activity Glutathione Disulfide Oxidoreductase Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Endocytosis Protein Transport Endocytic Recycling Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production	Regulation Of DNA-templated Transcription Glutathione Metabolic Process Apoptotic Process Response To Temperature Stimulus Regulation Of Signal Transduction Cell Differentiation DNA Protection Cell Redox Homeostasis Response To Redox State
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs			Glutathione
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)
Interacting Genes		7 interacting genes: ARF1 ARF4 ARF5 HOOK1 LNX1 RAB35 RBFOX2	4 interacting genes: DCXR ELF5 FBXO7 TXNRD1
Entrez ID		163486	51022
HPRD ID		13303	12112
Ensembl ID		ENSG00000213047	ENSG00000023572
Uniprot IDs		Q6P3S1	Q9NS18
PDB IDs		3TW8	2CQ9 2FLS 2HT9
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Establishment Of Localization In Cell Vesicle-mediated Transport Protein Transport Intracellular Transport Mitotic Cleavage Furrow Ingression Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Arsenate Reductase (glutaredoxin) Activity Chloride-activated Potassium Channel Activity Intracellular Sodium-activated Potassium Channel Activity Establishment Of Protein Localization Cleavage Furrow Ingression Phospholipase D Activator Activity Glutathione Disulfide Oxidoreductase Activity Cellular Localization	NADPH Peroxidase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite L-xylulose Reductase (NADPH) Activity Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Ectodermal Cell Fate Commitment Xylulose Metabolic Process Protein Localization To Nuclear Pore Lewy Body Core D-xylose Metabolic Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Oxidoreductase Activity, Acting On CH-OH Group Of Donors D-glucuronate Catabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate Nuclear Pore Central Transport Channel Thioredoxin-disulfide Reductase (NADPH) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carbonyl Reductase (NADPH) Activity Positive Regulation Of T-helper 2 Cell Cytokine Production Pentose Metabolic Process
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